DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sff and prk-2

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_497696.2	Gene:	prk-2 / 175437	WormBaseID:	WBGene00004183	Length:	441	Species:	Caenorhabditis elegans

Alignment Length:	503	Identity:	127/503 - (25%)
Similarity:	198/503 - (39%)	Gaps:	118/503 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLM---KVEREIAIM-KLID 73
            :|...|:|:..||:|..|:|...|.......||:|.|.|..:.|...:   :|..||.:: |...
Worm    26 KFKKNYKLKAELGRGGFGVVYRAVRTCDNALVAVKFIERSNVKEWARINGEQVPMEICMLAKCSK 90

  Fly    74 HPHVLGLSDVYENKKYLYLILEH-VSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSIC 137
            ...|:.|.|.|...:...:::|. ....::||::..:|:::...||..||||...:..|..:.:.
Worm    91 VRGVIRLLDWYSIPEGFLIVMERPYPCIDMFDFIKGQGKISEDMARFLFRQIAVTVHECVQNRVL 155

  Fly   138 HRDLKPENLLLD-EKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSC 201
            |||||.||:::| ...:.|:.|||.|::. ..|......|:..|..||......|.||:|.|||.
Worm   156 HRDLKDENIVIDLVTGSTKLIDFGAATVL-RRSQYSDFQGTRLYCPPEWFLHSLYLGREAAVWSL 219

  Fly   202 GVILYALLVGALPFDDDN---LRQLLEKVKRGVFHIPHFVP--PDCQSLLRGMIEVNPDRRLTLA 261
            ||:||..|.|.|||.::.   ...||..       :|.|||  .:.:.|:...:..:|.:|.:|.
Worm   220 GVLLYNSLNGRLPFRNEKDICTAHLLGP-------LPFFVPVSAEVKDLISKCLTFDPFQRCSLE 277

  Fly   262 EINRHPWVTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSS 326
            .|..||||..                ||        :..|.|.          |.|:.::...||
Worm   278 AILNHPWVKQ----------------QT--------LSWDALT----------KNKVQKKTSESS 308

  Fly   327 --HNTEKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSY--GQI 387
              |::|               .|.|..| .::.||      ||           |::.|.  |..
Worm   309 DDHHSE---------------TLGDHSE-TEEDRS------PP-----------TSSVSQQPGSA 340

  Fly   388 SEGSPLTPRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANAISRPS 452
            .||..|          |.||:..|.::.|.      ......:.|...:|.:|.:.:| |:....
Worm   341 DEGVGL----------SASSSNTHNQKKPN------HKEFRMAKTSLLAPPTSIEMKA-AVQASK 388

  Fly   453 SPAAGTRHSTY-GDRDRSGHHS----------SVSRTPSHSSQKSIEG 489
            :|.....|:.. ..|....|||          ::.|..|..:|..|.|
Worm   389 TPTQFNVHTALKNQRQIKKHHSPQPPNSTVLTALRRAMSREAQNRISG 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	80/263 (30%)
		S_TKc	18..269	CDD:214567	80/261 (31%)
		UBA_BRSK	298..350	CDD:270525	9/53 (17%)
prk-2	NP_497696.2	STKc_PIM	30..285	CDD:270907	80/262 (31%)
prk-2	NP_497696.2	Pkinase	31..285	CDD:278497	80/261 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910