Protein Alignment sff and Mark3

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: XP_006515574.1
• Gene: Mark3 / 17169
• MGIID: 1341865
• Length: 806
• Species: Mus musculus
• Alignment Length: 830
• Identity: 249/830 - (30%)
• Similarity: 385/830 - (46%)
• Gaps: 161/830 - (19%)

  Fly     9 AENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLID 73
            |:....:|.|||.||:|||....|||..|.:.|::||||||::.:|:.:.|.|:.||:.|||:::
Mouse    47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN 111

  Fly    74 HPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 138
            ||:::.|.:|.|.:|.||||:|:.||||:|||||..||:..||||..||||:||:.:||...|.|
Mouse   112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVH 176

  Fly   139 RDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGV 203
            ||||.||||||...||||||||.::....||.|:|.||||.||.||:.:|:||||.:.||||.||
Mouse   177 RDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGV 241

  Fly   204 ILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPW 268
            |||.|:.|:||||..||::|.|:|.||.:.||.::..||::||:..:.:||.:|.||.:|.:..|
Mouse   242 ILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRW 306

  Fly   269 VTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVI 333
            :.||.: |.||: |.:|       |.....|...::.:..:|..:|:   |||.||.....|...
Mouse   307 INAGHE-EDELK-PFVE-------PELDISDQKRIDIMVGMGYSQEE---IQESLSKMKYDEITA 359

  Fly   334 YFLLLERKRRRPALEDDDEIAQKSRSELDAVDPP----------RKRLDTCRINGTNAPSYGQIS 388
            .:|||.||                .:||||.|..          |...|.....|.:....||.|
Mouse   360 TYLLLGRK----------------SAELDASDSSSSSNLSLAKVRPNSDLSNSTGQSPHHKGQRS 408

  Fly   389 EGS------------PLTPRRQAFNFRSYSSTRNH--------QRRSPTTVT-------SSVRSS 426
            ..|            |..|...|:..||.:||.:.        .|:|.::..       :|....
Mouse   409 VSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGIPSRKSSSSAVGGKGIAPASPMLG 473

  Fly   427 SYHSPTRCNSPMSSAQQQANAISRPSSPAAG---TRHSTY--GDRDRSGHHSSVSRTPSHSSQKS 486
            :..:|.:.:.|   .::::.|:  |||..|.   ||.:||  .:|..:..||.:    .:..:.|
Mouse   474 NAGNPNKADIP---ERKKSPAV--PSSNTASGGMTRRNTYVCSERCAADRHSVI----QNGKENS 529

  Fly   487 IEGDVVVVREPRIERRDS---LRQER-----GGGSPR-------DRGD----CGIP-PGSPGGNS 531
            :.........|......|   ||.:|     ..|.|:       ..||    ..|| ..:|..::
Mouse   530 LTEVFAYAASPASLCATSTCRLRHQRSMSVSASGHPKMVLPPIDSEGDTFKAIAIPDERTPVAST 594

  Fly   532 SGSTSASPSVHHRANSGPTIAISMFH-DPDSNSVVNPNGSPMMNNSSPGM-----PGSPCNTPGG 590
            ...:||:.....|...| |.:.|.|| .|........||.|    :||.:     |.|...:.|.
Mouse   595 HSISSATTPDRIRFPRG-TASRSTFHGQPRERRTATYNGPP----ASPSLSHEATPLSQTRSRGS 654

  Fly   591 QLWKTRLTN--------------IKNSFLGSPRFHRRKMQVSADEVHLTPESSPELTKRSWFGNL 641
            ....::||:              :...:..:.|:......||:::.....|:.|...:.:|  ::
Mouse   655 TNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSSEQKDENREAKPRSLRFTW--SM 717

  Fly   642 ITTEKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKR-------NGNGPVM 699
            .||...:...:                    |.|: ..|:...:...|.:.       :|:|..
Mouse   718 KTTSSMDPSDM--------------------MREI-RKVLDANNCDYEQRERFLLFCVHGDGHA- 760

  Fly   700 FQRHVKFQVDISAICKQGDIADMLFALTFTLLSGNIRRFRRICEHIQSQV 749
             :..|:::::   :||...::  |..:.|..:||....|:.|...|.:::
Mouse   761 -ENLVQWEME---VCKLPRLS--LNGVRFKRISGTSIAFKNIASKIANEL 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	133/252 (53%)
		UBA_BRSK	298..350	CDD:270525	14/51 (27%)
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	132/251 (53%)
		UBA_MARK3_4	325..367	CDD:270590	12/44 (27%)
		MARK1-3_C	707..804	CDD:213381	20/126 (16%)