Protein Alignment sff and SIK1

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_775490.2
• Gene: SIK1 / 150094
• HGNCID: 11142
• Length: 783
• Species: Homo sapiens
• Alignment Length: 742
• Identity: 224/742 - (30%)
• Similarity: 325/742 - (43%)
• Gaps: 178/742 - (23%)

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLG 79
            ||.|.:|:|||||...:|||..|.|...:||||||::.:|..|.|.|:.||:.:|||::|||::.
Human    24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIK 88

  Fly    80 LSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPE 144
            |..|.|.|..||::.|....||:||||...|.|:..||||.|.||:||:::||.|.|.|||||.|
Human    89 LYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTE 153

  Fly   145 NLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALL 209
            |||||...:||:||||..:...:|..|.|.||||.||.|||..|::|:|.:.|:||.||:||.|:
Human   154 NLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLV 218

  Fly   210 VGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGGK 274
            .|:||||..||..|.::|..|.|.||.|:..||:||:|.|:.|:|.||:|:|:|.:|.|:.|
Human   219 CGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRA--- 280

  Fly   275 GELELELPMMEVVQTHVIPTATA-VDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYFLLL 338
             |..|..|.......|...:... .|...|..:.:||.  ::::.::.|.:||:|....||:|||
Human   281 -EPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGV--DRQRTVESLQNSSYNHFAAIYYLLL 342

  Fly   339 ERKR-------------RRPALEDDD----EIAQKS-----------------------RSELDA 363
            ||.:             |:|.....|    |:.|:.                       ::|:|.
Human   343 ERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDC 407

  Fly   364 -------------VD------------PPRKRLDTC----------------------------- 374
                         ||            .|...|||.
Human   408 ELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRH 472

  Fly   375 -------RINGTNAPSYGQISEGSPLTPRR--QAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHS 430
                   |::...||.. .:|..:..:|..  .:.:..::|::::....|.|..|..:..:.  |
Human   473 TLAEVSTRLSPLTAPCI-VVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGAC--S 534

  Fly   431 PTRCNSPMSSAQQ-----QA-----NAISRPSSPAAGTRHS----TYGDRDRSGHHSSVSRTPSH 481
            |.|..||...:|.     ||     .|:..|.|...|.|.|    |.|.:.........:||...
Human   535 PVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGF 599

  Fly   482 SSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGIPPGSPG--GNSSGSTSASPSV--- 541
            .....|:|   :.|:  :.:..:.|..|||.||     ...|..|||  |.::||......:
Human   600 LGLNKIKG---LARQ--VCQAPASRASRGGLSP-----FHAPAQSPGLHGGAAGSREGWSLLEEV 654

  Fly   542 ----------HHRANSGPTIAISMFHDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPG-GQLWKT 595
                      ||.|.:           |..:....|..:|.:.        :||:.|| ..|..|
Human   655 LEQQRLLQLQHHPAAA-----------PGCSQAPQPAPAPFVI--------APCDGPGAAPLPST 700

  Fly   596 RLTNIKNSFLGSPRFHRRKMQVSADEV 622
            .||:      |.|......:|..|..|
Human   701 LLTS------GLPLLPPPLLQTGASPV 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	127/252 (50%)
		UBA_BRSK	298..350	CDD:270525	17/64 (27%)
SIK1	NP_775490.2	STKc_SIK	26..278	CDD:270973	126/251 (50%)
		UBA_SIK1	300..349	CDD:270591	15/50 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..377		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..477		0/27 (0%)
		RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305|PubMed:29211348	583..612		5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	619..643		11/28 (39%)