Protein Alignment sff and Chek1

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_031717.2
• Gene: Chek1 / 12649
• MGIID: 1202065
• Length: 476
• Species: Mus musculus
• Alignment Length: 282
• Identity: 90/282 - (31%)
• Similarity: 157/282 - (55%)
• Gaps: 20/282 - (7%)

  Fly    14 FVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVL 78
            ||..:.|.:|||:|..|.|:|.|:.:..:.||:||::.::..:.. ..:::||.|.|::.|.:|:
Mouse     5 FVEDWDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAIDCP-ENIKKEICINKMLSHENVV 68

  Fly    79 GLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKP 143
            ............||.||:.|||||||.:.....:..::|::||.|:::.:.:.|...|.|||:||
Mouse    69 KFYGHRREGHIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKP 133

  Fly   144 ENLLLDEKNNIKIADFGMASL---QPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL 205
            |||||||::|:||:|||:|::   .....:|...||:..|..||:::.:::.....||||||::|
Mouse   134 ENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVL 198

  Fly   206 YALLVGALPFD--DDNLRQLLE-KVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHP 267
            .|:|.|.||:|  .|:.::..: |.|:...:....:.....:||..::...|..|:|:.:|.:..
Mouse   199 TAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVETPSARITIPDIKKDR 263

  Fly   268 W-------------VTAGGKGE 276
            |             .|:||..|
Mouse   264 WYNKPLNRGAKRPRATSGGMSE 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	84/271 (31%)
		UBA_BRSK	298..350	CDD:270525
Chek1	NP_031717.2	Interaction with CLSPN. /evidence=ECO:0000250	1..265		85/260 (33%)
		STKc_Chk1	7..265	CDD:270971	83/258 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	267..331		4/19 (21%)
		Autoinhibitory region. /evidence=ECO:0000250	391..476