DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sff and PIM2

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_006866.2	Gene:	PIM2 / 11040	HGNCID:	8987	Length:	311	Species:	Homo sapiens

Alignment Length:	273	Identity:	95/273 - (34%)
Similarity:	144/273 - (52%)	Gaps:	31/273 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREK------LSESVLMKVEREIAIMKLI 72
            |...|||...||||..|.|..|.......:||||:|.|.:      ||:||...:  |:|::..:
Human    28 FEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL--EVALLWKV 90

  Fly    73 ----DHPHVLGLSDVYENKKYLYLILEH-VSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 132
                .||.|:.|.|.:|.::...|:||. :...:||||:.:||.|....:|.||.|:::|:..||
Human    91 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCH 155

  Fly   133 SHSICHRDLKPENLLLD-EKNNIKIADFGMASLQPAGSMLETS-----CGSPHYACPEVIRGEKY 191
            |..:.|||:|.||:|:| .:...|:.|||      :|::|...     .|:..|:.||.|...:|
Human   156 SRGVVHRDIKDENILIDLRRGCAKLIDFG------SGALLHDEPYTDFDGTRVYSPPEWISRHQY 214

  Fly   192 DGRKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDR 256
            ....|.|||.|::||.::.|.:||:.|  :::||    ...|.|..|.|||.:|:|..:...|..
Human   215 HALPATVWSLGILLYDMVCGDIPFERD--QEILE----AELHFPAHVSPDCCALIRRCLAPKPSS 273

  Fly   257 RLTLAEINRHPWV 269
            |.:|.||...||:
Human   274 RPSLEEILLDPWM 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	93/269 (35%)
		S_TKc	18..269	CDD:214567	93/267 (35%)
		UBA_BRSK	298..350	CDD:270525
PIM2	NP_006866.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		STKc_PIM2	31..287	CDD:271003	94/270 (35%)
		S_TKc	32..286	CDD:214567	93/267 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910