Protein Alignment sff and Prkaa1

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: XP_036014946.1
• Gene: Prkaa1 / 105787
• MGIID: 2145955
• Length: 589
• Species: Mus musculus
• Alignment Length: 601
• Identity: 188/601 - (31%)
• Similarity: 274/601 - (45%)
• Gaps: 173/601 - (28%)

  Fly    15 VGPYRLEKTLGKGQTGLVK-----------LG-----------VH--CVIGK------KVAIKII 49
            :|.|.|..|||.|..|.||           ||           ||  |::||      |||:||:
Mouse    24 IGHYILGDTLGVGTFGKVKVPEKGYTDARLLGTLPQQQYLNSYVHIDCLVGKHELTGHKVAVKIL 88

  Fly    50 NREKL-SESVLMKVEREIAIMKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLT 113
            ||:|: |..|:.|:.|||..:||..|||::.|..|......:::::|:|||||||||:.|.|||.
Mouse    89 NRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLD 153

  Fly   114 PKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSP 178
            .||:|:.|:||:|.:|:||.|.:.||||||||:|||...|.||||||::::...|..|.||||||
Mouse   154 EKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP 218

  Fly   179 HYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQ 243
            :||.||||.|..|.|.:.|:||.||||||||.|.||||||::..|.:|:..|:|:.|.::.|...
Mouse   219 NYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVI 283

  Fly   244 SLLRGMIEVNPDRRLTLAEINRHPWVTAGGKGELELELPMMEVVQTHVIP-----TATAVDPDVL 303
            |||:.|::|:|.:|..:.:|..|.|        .:.:||      .::.|     ::|.:|.:.|
Mouse   284 SLLKHMLQVDPMKRAAIKDIREHEW--------FKQDLP------KYLFPEDPSYSSTMIDDEAL 334

  Fly   304 NAIC-SLGCFKEKEKLIQELLSSSHNTE-----KVIYFLLLERKRRRPALED------------D 350
            ..:| ...|.:|      |:||..:|..     .|.|.|:::.:|.....:|            |
Mouse   335 KEVCEKFECSEE------EVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLD 393

  Fly   351 DE-------------IAQ--KSRSELDAVDPPRKR-----------------------LDTCR-- 375
            |.             :|:  ::|..||.::|.:.:                       .:.||
Mouse   394 DHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAI 458

  Fly   376 ---------INGTNAPSYGQISEGSPLT--------------PRRQAFNFRSYSSTRNHQRRSPT 417
                     :|    |.|.::...:|:|              .|....:|||........:....
Mouse   459 KQLDYEWKVVN----PYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTA 519

  Fly   418 TVTSSVRSSSYHSPTRCNSPMSSAQQQANAISRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHS 482
            |...|...|:|.|..|.:|                            |.:..|..|.||.|.|.:
Mouse   520 TPQRSGSISNYRSCQRSDS----------------------------DAEAQGKPSDVSLTSSVT 556

  Fly   483 SQKSIEGDVVVVREPR 498
            |..|...||.    ||
Mouse   557 SLDSSPVDVA----PR 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	131/283 (46%)
		UBA_BRSK	298..350	CDD:270525	14/69 (20%)
Prkaa1	XP_036014946.1	STKc_AMPK_alpha	24..309	CDD:270981	132/292 (45%)
		UBA_AID_AAPK1	326..390	CDD:270586	15/69 (22%)
		AMPKA1_C	434..587	CDD:213384	31/171 (18%)