DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sff and brsk1

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_004916361.1	Gene:	brsk1 / 100491623	XenbaseID:	XB-GENE-1013495	Length:	834	Species:	Xenopus tropicalis

Alignment Length:	884	Identity:	440/884 - (49%)
Similarity:	558/884 - (63%)	Gaps:	105/884 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDH 74
            ::.|:||||||||||||||||||||||||:.|:||||||:|||||||||||||||||||:|||:|
Frog    17 QHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 81

  Fly    75 PHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHR 139
            ||||.|.|||||||||||:||||||||||||||||||||||||||||||||||||||||:|||||
Frog    82 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSYSICHR 146

  Fly   140 DLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVI 204
            |||||||||||||||:||||||||||...|:||||||||||||||||:|||||||:|||||||||
Frog   147 DLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADVWSCGVI 211

  Fly   205 LYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWV 269
            |:|||||||||||||||||||||||||||:|||:||:||:||||||||.|::||:|.:|.:|.|.
Frog   212 LFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPECQNLLRGMIEVEPEKRLSLEQIQKHSWY 276

  Fly   270 TAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIY 334
             .|||.|.|.|.|....|....|.:.:..|||||:::.|||||::|.||.|||.:...|.||:||
Frog   277 -LGGKNEPEPEQPTPRKVAIRRIHSVSEFDPDVLDSMHSLGCFRDKTKLKQELQNEDENQEKMIY 340

  Fly   335 FLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRIN--GTNAPSYG-----QISEGSP 392
            :|||:||.|.|:.||:|   ...|::   :||||||:|:..:|  |...|...     .:::|..
Frog   341 YLLLDRKERYPSCEDED---LPPRND---IDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGS 399

  Fly   393 LTPRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSP--TRCNSPMSSAQ-------QQANAI 448
            ..|.|:|.....:|. |:......:|..||...||..||  |...:|:..|:       .|:.|.
Frog   400 PVPARRAIEMAQHSQ-RSRSVSGASTGLSSSPLSSPRSPVFTFSPTPLEPAEGEDPRAIWQSKAA 463

  Fly   449 SRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGS 513
            .|...|...|..:          .:|:...|.|:.:.:.....:....|..:...|  ..|...|
Frog   464 HRQPDPKTQTLPA----------KTSLGEKPLHTIKSNPLPITMAASSPPHDSSSS--PHRSPLS 516

  Fly   514 PRDRGDCGIPPGSPGGNSSGSTSASPSV------HHRANSG---PTIAISMFHDPDSNSVVNPNG 569
            |.     ..|...|.....|:.||:.||      .|.:..|   ||...:..|.|..:....|:|
Frog   517 PP-----FFPTSLPARFFPGTKSATKSVPLPQVTPHPSPRGSPLPTPLGTPVHTPKDSPTGTPSG 576

  Fly   570 SPMMNNSSPGMPGSPCNTPGGQLWKTRLTNIKNSFLGSPRFHRRKMQVSADE--VHLTPESSPEL 632
            :|   .||||:        ||..|||||.:|||||||||||||||:||...|  ..|||||||||
Frog   577 TP---PSSPGV--------GGVAWKTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSSLTPESSPEL 630

  Fly   633 TKRSWFGNLITTEKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKRNGNGP 697
            .|:|||||.|..:|:|...:::|.||::::||.::|||||:..|||||:|.||||.|||.:| ||
Frog   631 AKKSWFGNFINLDKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKSSG-GP 694

  Fly   698 VMFQRHVKFQVDISAICKQGDIADM---LFALTFTLLSGNIRRFRRICEHIQSQVCSKRFPGPSS 759
            .:||:.||||||||  ..:|..|..   ::::||||:||..|||:|:.|.||:|:.|..     .
Frog   695 SVFQKPVKFQVDIS--YSEGAEAQKENGIYSVTFTLISGPSRRFKRVVETIQAQLLSTH-----D 752

  Fly   760 PPTVTSVTQAVSESSSCGSVSSERLSYKRQVIENDMENDSIFSYKSGNGRRASTTNNNNANPVDI 824
            .|:|    ||::.|:...          |..:|..:::.........||:::..
Frog   753 QPSV----QALAGSNVTA----------RTQMECSLDHLLFLPPDEKNGQQSRP----------- 792

  Fly   825 PGSPI-----AVRSNSETAEHERNRELQSERQATTMSGS 858
            ||:|.     :.||..:.|||.| |....:::....:|:
Frog   793 PGTPTRSCQNSRRSEPDMAEHHR-RGSSKDKKLLASNGT 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	221/252 (88%)
		S_TKc	18..269	CDD:214567	219/250 (88%)
		UBA_BRSK	298..350	CDD:270525	29/51 (57%)
brsk1	XP_004916361.1	STKc_BRSK1_2	23..276	CDD:270983	221/252 (88%)
brsk1	XP_004916361.1	UBA_BRSK	303..356	CDD:270525	29/52 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	465	1.000	Domainoid score	I464
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	745	1.000	Inparanoid score	I582
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	1	1.000	-	-		FOG0002008
OrthoInspector	1	1.000	-	-		otm47896
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1318
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160