Protein Alignment sff and prkaa1

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_001120434.1
• Gene: prkaa1 / 100145520
• XenbaseID: XB-GENE-946195
• Length: 551
• Species: Xenopus tropicalis
• Alignment Length: 542
• Identity: 177/542 - (32%)
• Similarity: 269/542 - (49%)
• Gaps: 104/542 - (19%)

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKL-SESVLMKVEREIAIMKLIDHPHVL 78
            :|.|.|..|||.|..|.||:|.|.:.|.|||:||:||:|: |..|:.|:.|||..:||..|||::
 Frog    15 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHII 79

  Fly    79 GLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKP 143
            .|..|......:::::|:|||||||||:.|.|:|..||:|:.|:||:|.:|:||.|.:.||||||
 Frog    80 KLYQVISTPTDIFMVMEYVSGGELFDYICKNGKLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 144

  Fly   144 ENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYAL 208
            ||:|||...|.||||||::::...|..|.||||||:||.||||.|..|.|.:.|:||||||||||
 Frog   145 ENVLLDAHMNAKIADFGLSNMMADGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL 209

  Fly   209 LVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGG 273
            |.|.||||||::..|.:|:..|:|:.|.::.|...|||:.|:.|:|.:|.|:.:|..|.|
 Frog   210 LCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPPVISLLKHMLLVDPMKRATIKDIREHEW----- 269

  Fly   274 KGELELELPMMEVVQTHVIP-----TATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTE-KV 332
               .:|:||      .::.|     ::..:|.:.|..:|. .|...:|:::..|.|.:|... .|
 Frog   270 ---FKLDLP------KYLFPEDPSYSSNMIDDEALKEVCE-KCECLEEEVLSCLYSRNHQDPLAV 324

  Fly   333 IYFLLLERKRRRPALED-------------DDEIAQ--------------KSRSELDAVDPPRKR 370
            .|.|:::.:|.....:|             :.::|:              :.|..||.::|.:.:
 Frog   325 AYHLIIDNRRIMNEAKDFYLATSPPDSFMEEPQVARPHPERVPFLVAESPRQRHTLDELNPQKTK 389

  Fly   371 ------------------------LDTCR-----------INGTNAPSYGQISEGSPLT------ 394
                                    .:.||           :|    |.|.::...:|:|
 Frog   390 HQVGVRRAKWHLGIRSQSRPNDIMAEVCRAMKQLGYEWKVVN----PYYLRVRRKNPVTSMYTKM 450

  Fly   395 --------PRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANAISRP 451
                    .|....:|||........:....|...|...|:|..|...:.|  ..|.:::..|.|
 Frog   451 SLQLYQVDSRTYLLDFRSIDDEVTEAKSESATPRRSGSISNYRPPKNDSDP--EIQAKSSDGSGP 513

  Fly   452 SSPAAGTRHSTYGDRDRSGHHS 473
            ||..:....|......|.|.|:
 Frog   514 SSLTSSVDSSNADLVPRPGSHT 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	128/253 (51%)
		UBA_BRSK	298..350	CDD:270525	13/65 (20%)
prkaa1	NP_001120434.1	STKc_AMPK_alpha	15..270	CDD:270981	129/262 (49%)
		UBA_AID_AAPK1	287..351	CDD:270586	13/64 (20%)
		AMPKA1_C	396..549	CDD:213384	26/146 (18%)