DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-1 and glrb

DIOPT Version :9

Sequence 1:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_001072255.1	Gene:	glrb / 779708	XenbaseID:	XB-GENE-1011734	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	390	Identity:	99/390 - (25%)
Similarity:	169/390 - (43%)	Gaps:	90/390 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 SSSDKEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRG-TLTVNVNVLLLS 397
            ::|...||:.||..  ||.|:                         ||:.:| .:.|.||:.:.|
Frog    53 ANSTSNILNRLLVS--YDPRV-------------------------RPNFKGIPVDVVVNIFINS 90

  Fly   398 LASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHHDS----------IWTPDTYFI- 451
            ..|..|:::.|.|...|.|:||||||:..|    ||..:    |:          :|.||.:|.
Frog    91 FGSIQETTMDYRVNIFLRQRWNDPRLKLPN----DFRGS----DALTVDPTMFKCLWKPDLFFAN 147

  Fly   452 -MHGDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQI 515
             .:.:|.| :...:..|.|||:|.:..:||..:.|||...|.:||.|..:|...:||..|....:
Frog   148 EKNANFHD-VTQENILLFIFRDGDVLLSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDL 211

  Fly   516 KYVWKNDEDTLRKSPSLTTLNAYLIKNQTTA---CDQ-NSWRGNYSCLQVELTFTRDRAYYFTTV 576
            :::|::.:....:..:|...:   ||.:...   |.: ....|.|:|::|..|..|...:|...|
Frog   212 RFIWQSGDPVQMEKIALPQFD---IKTEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGV 273

  Fly   577 FIPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMC 641
            :.|.:::|..|:::||:..:|..|||.:|:.::|:..:........||.||.:.|::||...|:.
Frog   274 YAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAQELPKVSYVKAIDVWLIACLL 338

  Fly   642 FIYASLLEFVCVNYV----------------------------------GRKRPLHNVVYRPGEN 672
            |.:|||:|:..|..:                                  |...|:|....:.|||
Frog   339 FGFASLVEYAVVQVLLNSPKRIEAEKAKIAKAEQAEGKGANAAKKNTVNGTGTPIHISTLQVGEN 403

Fly 673 672
Frog 404 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	64/244 (26%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	31/129 (24%)
glrb	NP_001072255.1	LIC	38..496	CDD:273305	99/390 (25%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	54/197 (27%)
		Cys-loop	183..197	CDD:349811	5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614790at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020