DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-1 and gabrp

DIOPT Version :9

Sequence 1:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	XP_005173350.1	Gene:	gabrp / 566633	ZFINID:	ZDB-GENE-081028-62	Length:	464	Species:	Danio rerio

Alignment Length:	719	Identity:	135/719 - (18%)
Similarity:	242/719 - (33%)	Gaps:	282/719 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 AFQYLGQHYKHYSQSISFYAASSVLLMLCYLTTASTAAATQSETGALDKHPIHGIDWSKFDESSS 336
            ::|..|.||.....::.|:  :|:.|::           |..|.|      .:|..:.::::|..
Zfish     9 SYQSSGLHYHRMLLNLLFW--TSLFLLI-----------TNGERG------FYGNQYGEWNDSQL 54

  Fly   337 DKEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASP 401
            ...|..|:   |.|::.|.|..|:                        |.:.:.:::.:.|:.:.
Zfish    55 QPTIQKLM---KGYNRYLRPNFNE------------------------GPVEIGMSLDIASIDAI 92

  Fly   402 DESSLKYEVEFLLNQQWNDPRLQY-GNKS-HYD-FLNALHHHDSIWTPDTYFIMHG--DFKDPII 461
            .|.::.|.....|.|:|.|.||.: ||:| ..| .|.:|     :|.||| ||...  .|...:.
Zfish    93 SEINMDYTATIFLRQRWRDSRLIFPGNESLSLDGRLVSL-----LWIPDT-FIPDSKRSFLHDVT 151

  Fly   462 PMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTL 526
            ..:..:|||.|||:.||:|....::|...|..:|.|..:|:..:||..|....:.:.|....|::
Zfish   152 VENRLIRIFSNGTVLYALRITATIACNMDLTKYPMDRQECTLQLESWGYNLEDVVFYWTRGNDSV 216

  Fly   527 RKSPSLTTLNAYLIKNQTTACDQNSWR-GNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFIT 590
            :...:| .|..|.:::..|:..:..:. |.|..|.:.....|:..::....::|..:||..|:::
Zfish   217 KGLDTL-RLAQYSVESYYTSVTKAVYETGLYPKLILHFALRRNVLFFILETYVPSTLLVVLSWVS 280

  Fly   591 FWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVS-NLTAMNVWDGVCMCFIYASLLEFVCVN 654
            ||:..::||||..|||||:|...|...|.|::||..: .:.|::|:.|:|..||:.:|||:.|.:
Zfish   281 FWISQSSVPARTCIGVTTVLTMTTLMMGARTSLPNANCFIKAIDVYLGICFTFIFGALLEYACAH 345

  Fly   655 YVGRKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPMSSGTPAAS 719
            :
Zfish   346 F---------------------------------------------------------------- 346

  Fly   720 SSVATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPT 784
                                             ..:|:.....::|:..:.
Zfish   347 ---------------------------------CTMQHQTIIDVQRELLKE-------------- 364

  Fly   785 EHIYEEPGGST---SGVTSTKVKFKDELKEEQPEEAESSTKLRRSVATSTPALVVRIEAEIDPEA 846
               :||..|:|   |.::..|:|.:|..|:|:||:.
Zfish   365 ---FEESNGTTHLVSSMSPRKMKTEDSTKQEKPEQT----------------------------- 397

  Fly   847 EDKPIQDMEMTERQLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKRQNAGAPNEIVACTT 911
                                                                           .|
Zfish   398 ---------------------------------------------------------------VT 399

  Fly   912 CGGSNSPCTHSANNGCATETCFVQVRKK------EPPHPIRVAKTIDVIARITFPTAYAIFLIFF 970
            | ..|.....:...||...|.....|:.      |.||      .||..|||.||.|:.:..||:
Zfish   400 C-EENEAIEQTKEKGCGLTTVKQMSRRAASMMSVENPH------NIDRHARILFPMAFLLINIFY 457

  Fly   971 FVHY 974
            :::|
Zfish   458 WLYY 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	56/233 (24%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	31/104 (30%)
gabrp	XP_005173350.1	Neur_chan_LBD	21..461	CDD:332142	130/705 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910