DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pHCl-1 and GABRQ

DIOPT Version :9

Sequence 1:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_061028.3	Gene:	GABRQ / 55879	HGNCID:	14454	Length:	632	Species:	Homo sapiens

Alignment Length:	685	Identity:	154/685 - (22%)
Similarity:	259/685 - (37%)	Gaps:	162/685 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 KEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGT-LTVNVNVLLLSLASP 401
            ::|||.:|  .|||.||                         ||:..|. :.|.:::.:.|:...
Human    60 QKILDRVL--SRYDVRL-------------------------RPNFGGAPVPVRISIYVTSIEQI 97

  Fly   402 DESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNA---LHHHDSIWTPDTYFIMHGD-FKDPIIP 462
            .|.::.|.:....:|.|.|.||.|    :...||.   ...|:.:|.||.||:...| |...:..
Human    98 SEMNMDYTITMFFHQTWKDSRLAY----YETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTV 158

  Fly   463 MHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLR 527
            .:...::..:||:.|.:|.....:|...||.||.|...|:..:||..|....|...|.::.:.:.
Human   159 ENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIH 223

  Fly   528 KSPSLTTLNAYLIKNQTTACDQNSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFW 592
            .:..|.......:....|:.:...:.|:|..|.::....|:...|...|:.|.::...:|:|:||
Human   224 MTEELHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFW 288

  Fly   593 LEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVG 657
            :.:::..|||.||:|:||...|..:..|..||.:|.:.|::::..||:.|::.||||:|.:||:.
Human   289 MNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLF 353

  Fly   658 RKRPLHNVVYRPGENPVTQRLP-AVLSRI---GVILASPLASAAATPAMSMMGGATPMSSGTPAA 718
            ..|       .|...|...|.| .|::|.   .|::.            ::..|...:..|   .
Human   354 YSR-------GPRRQPRRHRRPRRVIARYRYQQVVVG------------NVQDGLINVEDG---V 396

  Fly   719 SSSVATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRP 783
            ||...||....:..||.               :|:.........:....:.||.||:|.......
Human   397 SSLPITPAQAPLASPES---------------LGSLTSTSEQAQLATSESLSPLTSLSGQAPLAT 446

  Fly   784 TEHIYEEPGGSTSGVTSTKVKFKDELKEEQPEEAESSTKLRRSVATSTPALVVRIEAE---IDPE 845
            .|.:.:.|..|.....|..|:|..    .|.:::...|::|.           |:||.   :..:
Human   447 GESLSDLPSTSEQARHSYGVRFNG----FQADDSIIPTEIRN-----------RVEAHGHGVTHD 496

  Fly   846 AEDKPIQDMEMTERQLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKR-QNAG-------- 901
            .||.. :.:...||....|          |..|...:           |||. |.||
Human   497 HEDSN-ESLSSDERHGHGP----------SGKPMLHH-----------GEKGVQEAGWDLDDNND 539

  Fly   902 -----APNEIVACTT--CGGSNSP--CTHSANNGCATE---TCFVQVRKKEPP------------ 942
                 |..|...|.|  ..|.|..  ..|......::|   :|        ||
Human   540 KSDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSC--------PPSPGCSFTEGFSF 596

  Fly   943 ---HPIRVAKTIDVIARITFPTAYAIFLIFFFVHY 974
               :|..|.| :|..:|..||.|:.:|.|.::|::
Human   597 DLFNPDYVPK-VDKWSRFLFPLAFGLFNIVYWVYH 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	53/232 (23%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	34/104 (33%)
GABRQ	NP_061028.3	Neur_chan_LBD	60..>353	CDD:332142	85/323 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..458		10/62 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..523		7/53 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910