Protein Alignment pHCl-1 and glrbb

DIOPT Version :10

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001003587.1
• Gene: glrbb / 445193
• ZFINID: ZDB-GENE-040801-106
• Length: 494
• Species: Danio rerio
• Alignment Length: 664
• Identity: 140/664 - (21%)
• Similarity: 229/664 - (34%)
• Gaps: 246/664 - (37%)

  Fly   334 SSSDKEILDLLLEKKRYDKRLLP-----PVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNV 393
            ::|...||:.||  ..||.|:.|     ||.|                             .||:
Zfish    53 ANSTSNILNKLL--ITYDPRIRPNFKGIPVED-----------------------------RVNI 86

  Fly   394 LLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHHD-----SIWTPDTYFI-- 451
            .:.|..|..|:::.|.|...|.|:||||||:.......|.|..    |     .:|.||.:|.
Zfish    87 FINSFGSIQETTMDYRVNIFLRQRWNDPRLRLPQDFKSDSLTV----DPKMFKCLWKPDLFFANE 147

  Fly   452 MHGDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIK 516
            ...:|.| :...:..|.|||||.:..:||..:.|||...|.:||.|..:|...:||..|....::
Zfish   148 KSANFHD-VTQENILLFIFRNGDVLISMRLSVTLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLQ 211

  Fly   517 YVWKNDEDTLRKSPSLTTLNAYLIKNQTTA---CDQ-NSWRGNYSCLQVELTFTRDRAYYFTTVF 577
            ::|::.:.......:|...:   ||.:...   |.: .:..|.|:|::|..|..|...:|...|:
Zfish   212 FMWQSGDPVQMDEIALPQFD---IKQEDIEYGNCTKYYAGTGYYTCVEVIFTLRRQVGFYMMGVY 273

  Fly   578 IPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCF 642
            .|.:::|..|:::||:..:|..|||.:|:.::|:..:......|.||.||.:.|:::|...|:.|
Zfish   274 APTLLIVVLSWLSFWINPDASAARVPLGILSVLSLSSECTSLASELPKVSYVKAIDIWLIACLLF 338

  Fly   643 IYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMG- 706
            .:|||:|:..|.                   |....|.:|......:|:...:...|||.:.:.
Zfish   339 GFASLVEYAVVQ-------------------VMLNSPKLLEAERAKIATKEKAEGKTPAKNTING 384

  Fly   707 -GATPMSSGTPAASSSVATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARS 770
             |:||:
Zfish   385 MGSTPI----------------------------------------------------------- 390

  Fly   771 PSTSISPHPSGRPTEHIYEEPGGSTSGVTSTKVKFKDELKEEQPEEAESSTKLRR---SVATSTP 832
                           |:      ||..||.|:.|          :...|.:.||.   |:..|.|
Zfish   391 ---------------HV------STLQVTETRCK----------KVCTSKSDLRTNDFSIVGSLP 424

  Fly   833 ALVVRIEAEIDPEAEDKPIQDMEMTERQLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKR 897
                               :|.|::.                        .|.:
Zfish   425 -------------------RDFELSN------------------------FDCY----------- 435

  Fly   898 QNAGAPNEIVACTTCGGSNSPCTHSANNGCATETCFVQVRKKEPPHPI--RVAKTIDVIARITFP 960
               |.|.|:       ||....:.:.||           :|..||.|:  ..||.||:.||..||
Zfish   436 ---GKPIEV-------GSAFSKSQAKNN-----------KKPPPPKPVIPSAAKRIDLYARALFP 479

  Fly   961 TAYAIFLIFFFVHY 974
            .::..|.:.::..|
Zfish   480 FSFLFFNVIYWSVY 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	LIC	339..>662	CDD:455710	92/338 (27%)
		LGIC_TM	<948..975	CDD:476813	10/27 (37%)
		TM4 helix	950..971	CDD:349850	7/20 (35%)
glrbb	NP_001003587.1	LIC	45..493	CDD:455710	139/662 (21%)
		LGIC_ECD	79..264	CDD:475126	56/221 (25%)