Protein Alignment pHCl-1 and nAChRalpha1

DIOPT Version :9

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 532
• Identity: 111/532 - (20%)
• Similarity: 184/532 - (34%)
• Gaps: 133/532 - (25%)

  Fly   366 GLQSP-------DMATNQNAR-RP--HNRGTLTVNVNVLLLSLASPDESSLKYEV---EFLLNQQ 417
            ||.:|       |:.:|.|.. ||  :|...|||.:.:.|..|.   :.:||.::   ...:.|:
  Fly    19 GLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLI---DVNLKNQIMTTNVWVEQE 80

  Fly   418 WNDPRLQYGNKSHYDFLNALH-HHDSIWTPDTYFIMHGDFKDPIIPMHFALRIFRNGTITYAMRR 481
            |||.:|:: |...|..::.|| ..:.||.||.....:.|....:..|..|: :...|.:.:....
  Fly    81 WNDYKLKW-NPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAI-LHHTGKVVWKPPA 143

  Fly   482 HLILSCQGSLHIFPFDDPKCSFSMESISYE--EAQIKYVWKN-DEDTLRKSPSLTTLNAYLIKNQ 543
            .....|:..:..||||:..|.....|.:|:  ...::::.:. |.|.:...   ..|..|.|..:
  Fly   144 IYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG---IDLQDYYISVE 205

  Fly   544 TTACDQNSWRGN--YSCLQ-------VELTFTRDRAYYFTTVFIPGIILVTSSFITFWL-----E 594
            .......:.|..  |||.:       ..||..|...:|...:.||.:.:...|.:.|:|     |
  Fly   206 WDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGE 270

  Fly   595 WNAVPARVMIGVTT-----------------MLNFFTTSNGFRSTLPVVSNLTAMNV-------- 634
            ..::...:::.:|.                 :|..:........||.||..:..:||
  Fly   271 KISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTH 335

  Fly   635 ----WDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAVLSRI---------- 685
                |  |...||.. |.:.:|:     :||       ..|.|...:.|.||:.:
  Fly   336 RMAPW--VQRLFIQI-LPKLLCI-----ERP-------KKEEPEEDQPPEVLTDVYHLPPDVDKF 385

  Fly   686 ------------GVILASPLASAAATPAMSMMGGATPMSSGTPAASSSVATPGTPRITDPEEFFG 738
                        |:    |...|:....::..||.:......|...||:..||    .|.:.|..
  Fly   386 VNYDSKRFSGDYGI----PALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPG----ADDDLFSP 442

  Fly   739 GGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISP---HPSGRPTEHIYEEPGGSTSGVTS 800
            .|:....:.|....||.              :.:..:||   .|..|..|...|   ||......
  Fly   443 SGLNGDISPGCCPAAAA--------------AAAADLSPTFEKPYAREMEKTIE---GSRFIAQH 490

  Fly   801 TKVKFKDELKEE 812
            .|.|.|.|..||
  Fly   491 VKNKDKFESVEE 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	52/225 (23%)
		Neur_chan_memb	578..>682	CDD:280999	25/137 (18%)
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	50/222 (23%)
		LIC	27..530	CDD:273305	108/524 (21%)
		Neur_chan_memb	247..530	CDD:280999	57/296 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100