Protein Alignment pHCl-1 and nAChRalpha7

DIOPT Version :9

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 113/587 - (19%)
• Similarity: 202/587 - (34%)
• Gaps: 199/587 - (33%)

  Fly   337 DKEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASP 401
            :|.:|..||:  .|:....|.||:.|                       .|.::..:.|:.:...
  Fly    61 EKRLLHALLD--NYNSLERPVVNESD-----------------------PLQLSFGLTLMQIIDV 100

  Fly   402 DESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALH---HHDSIWTPDTYFIMH--------GD 455
            ||.:........|..:|||..|:: |.|.:..:..|.   |.  :|.||.  :|:        |.
  Fly   101 DEKNQLLITNIWLKLEWNDMNLRW-NSSEFGGVRDLRIPPHR--LWKPDV--LMYNSADEGFDGT 160

  Fly   456 FKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWK 520
            :...::       :..||:..|........:|:..:..|||||.:|.....|.:|:..|:
  Fly   161 YATNVV-------VRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQL----- 213

  Fly   521 NDEDTLRKSPSLTTLNAYLIKNQTTACDQNSWRGN--YSCL---QVELTFT----RDRAYYFTTV 576
               |...:..:...:::::...:.........|..  |:|.   .:::||.    |...|||..:
  Fly   214 ---DLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNL 275

  Fly   577 FIPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNL-----TAMNVWD 636
            .:|.:::.:.:.:.|.|..:: ..::.:|||.:|:.....|....|:|..|:.     |..|
  Fly   276 IVPCVLIASMALLGFTLPPDS-GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFN--- 336

  Fly   637 GVCMCFIYAS--LLEFVCVNYVGRKRPLHNV-----------------VYRPGENPVTQRLPAVL 682
              |:.|:.||  :...:.:||..|....|.:                 :.|||:
  Fly   337 --CIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQ----------- 388

  Fly   683 SRIGVILASPLASAAATPAMSMMGGATPMSSGTPAASSSVATPGTPRITDPEEFFGGGMRWQEAH 747
              :|.....|                       |::|||.|:               |.:.|:
  Fly   389 --VGYECPPP-----------------------PSSSSSSAS---------------GEKKQQ-- 411

  Fly   748 GGIIGAAVQN--LRARSIKRKAA-------------RSPSTSISPHPSGRPTEH--IYEE----- 790
                   :||  |:.||.|...|             |..|.:: ||   :||.:  :|.:
  Fly   412 -------IQNVELKERSSKSLLANVLDIDDDFRCNHRCASATL-PH---QPTYYRTMYRQGDDGS 465

  Fly   791 --PGGSTSGVTSTKVKFKDELKEEQPEEAESSTKLRRSVATSTPALVVR----IEAEIDPEAEDK 849
              |.|....|...::           .||.|.|.|..| |....||:::    |..::..|.|..
  Fly   466 VGPVGPAGPVVDGRL-----------HEAISHTCLTSS-AEYELALILKELRWITEQLKKEDETS 518

  Fly   850 PI 851
            .|
  Fly   519 DI 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	45/243 (19%)
		Neur_chan_memb	578..>682	CDD:280999	24/127 (19%)
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	113/587 (19%)
		Neur_chan_LBD	61..268	CDD:280998	47/251 (19%)
		Neur_chan_memb	275..552	CDD:280999	63/328 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100