DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pHCl-1 and Gabrr1

DIOPT Version :9

Sequence 1:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_058987.3	Gene:	Gabrr1 / 29694	RGDID:	61900	Length:	480	Species:	Rattus norvegicus

Alignment Length:	372	Identity:	95/372 - (25%)
Similarity:	167/372 - (44%)	Gaps:	45/372 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 VNDEDFCCGLQSPDMATNQNARRPHNRG-TLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDP 421
            ::|.||              :.||...| .:.|.|:|.:.||.|..|..:.:.:...|...|.|.
  Rat    82 IDDHDF--------------SMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDE 132

  Fly   422 RLQYGNKSHYDFLNALHHHDSIWTPDTYFI------MHGDFKDPIIPMHFALRIFRNGTITYAMR 480
            ||.:.:.::............||.||.:|:      :|....|.::     ||:..:|.:.|::|
  Rat   133 RLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVM-----LRVQPDGKVLYSLR 192

  Fly   481 RHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLTTLNAYLIK--NQ 543
            ..:...|......||.|...||..:||.:|.|..:...||...|:| |:....:|:.:||:  :.
  Rat   193 VTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSL-KTDERISLSQFLIQEFHT 256

  Fly   544 TTACDQNSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVTT 608
            ||.....|..|.|:.|.:..|..|...::....:.|..::|..|:::||::..||||||.:|:||
  Rat   257 TTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITT 321

  Fly   609 MLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENP 673
            :|...|...|..:::|.||.:.|::::..|...|::.|:||:..|||:       ..|....|..
  Rat   322 VLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYL-------TTVQERKERK 379

  Fly   674 VTQRLPAVLSRIGVILASP----LASAAATPAMSMMGGATPMSSGTP 716
            :.:::.....     |..|    |.|:.:...::.:||..|.:...|
  Rat   380 LREKISCTCG-----LPQPRGVMLDSSYSDGEVNDLGGYMPENGEKP 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	55/216 (25%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	31/103 (30%)
Gabrr1	NP_058987.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..67
		LIC	76..479	CDD:273305	95/372 (26%)
		LGIC_ECD_GABAAR_rho	97..282	CDD:349806	50/190 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910