Protein Alignment pHCl-1 and GLRB

DIOPT Version :9

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_000815.1
• Gene: GLRB / 2743
• HGNCID: 4329
• Length: 497
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 147/659 - (22%)
• Similarity: 235/659 - (35%)
• Gaps: 233/659 - (35%)

  Fly   334 SSSDKEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRG-TLTVNVNVLLLS 397
            ::|...||:.||..  ||.|:                         ||:.:| .:.|.||:.:.|
Human    53 ANSTSNILNRLLVS--YDPRI-------------------------RPNFKGIPVDVVVNIFINS 90

  Fly   398 LASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNAL----HHHDSIWTPDTYFI--MHGDF 456
            ..|..|:::.|.|...|.|:||||||:.  .|.:...:||    ..:..:|.||.:|.  ...:|
Human    91 FGSIQETTMDYRVNIFLRQKWNDPRLKL--PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANF 153

  Fly   457 KDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKN 521
            .| :...:..|.|||:|.:..:||..:.|||...|.:||.|..:|...:||..|....::::|::
Human   154 HD-VTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQS 217

  Fly   522 -DEDTLRKSPSLTTLNAYLIKNQTTA---CDQ-NSWRGNYSCLQVELTFTRDRAYYFTTVFIPGI 581
             |...|.|    ..|..:.||.:...   |.: ....|.|:|::|..|..|...:|...|:.|.:
Human   218 GDPVQLEK----IALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTL 278

  Fly   582 ILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYAS 646
            ::|..|:::||:..:|..|||.:|:.::|:..:......:.||.||.:.|::||...|:.|.:||
Human   279 LIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFAS 343

  Fly   647 LLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPM 711
            |:|:..|..:     |:|          .:|:.|..:||          |.|..|..
Human   344 LVEYAVVQVM-----LNN----------PKRVEAEKARI----------AKAEQADG-------- 375

  Fly   712 SSGTPAASSSVATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSIS 776
            ..|..|..::|...|||
Human   376 KGGNVAKKNTVNGTGTP------------------------------------------------ 392

  Fly   777 PHPSGRPTEHIYEEPGGSTSGVTSTKVKFKDELKEEQPEEAESSTKLRR---SVATSTPALVVRI 838
                    .||      ||..|..|:.|          :...|.:.||.   |:..|.|
Human   393 --------VHI------STLQVGETRCK----------KVCTSKSDLRSNDFSIVGSLP------ 427

  Fly   839 EAEIDPEAEDKPIQDMEMTERQLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKRQNAGAP 903
                         :|.|::.                        .|.:              |.|
Human   428 -------------RDFELSN------------------------YDCY--------------GKP 441

  Fly   904 NEIVACTTCGGSNSPCTHSANNGCATETCFVQVRKKEPP-HPI--RVAKTIDVIARITFPTAYAI 965
            .|:                 |||.....  .:..||.|| .|:  ..||.||:.||..||..:..
Human   442 IEV-----------------NNGLGKSQ--AKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLF 487

  Fly   966 FLIFFFVHY 974
            |.:.::..|
Human   488 FNVIYWSIY 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	66/239 (28%)
		Neur_chan_memb	578..>682	CDD:280999	29/103 (28%)
GLRB	NP_000815.1	LIC	43..496	CDD:273305	146/657 (22%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	56/192 (29%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	247..253		1/5 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614790at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.020