Protein Alignment pHCl-1 and GLRA1

DIOPT Version :9

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001139512.1
• Gene: GLRA1 / 2741
• HGNCID: 4326
• Length: 457
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 129/456 - (28%)
• Similarity: 206/456 - (45%)
• Gaps: 89/456 - (19%)

  Fly   306 STAAATQSETGALDKHPIHGIDWSKFDESSSDKEILDLLLEK-KRYDKRLLPPVNDEDFCCGLQS 369
            |.||:.::|.......|:            |..:.||.|:.: ..||.|:
Human    19 SLAASKEAEAARSAPKPM------------SPSDFLDKLMGRTSGYDARI--------------- 56

  Fly   370 PDMATNQNARRPHNRG-TLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDF 433
                      ||:.:| .:.|:.|:.:.|..|..|:::.|.|...|.||||||||.| |:...|.
Human    57 ----------RPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAY-NEYPDDS 110

  Fly   434 L----NALHHHDSIWTPDTYFIMH-GDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHI 493
            |    :.|   ||||.||.:|... |.....|...:..|||.|||.:.|::|..|.|:|...|..
Human   111 LDLDPSML---DSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKN 172

  Fly   494 FPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLTTLNAYLIKNQTTA--CDQNSWRGNY 556
            ||.|...|...:||..|....:.:.|: ::..::.:..| ||..:::|.:...  |.::...|.:
Human   173 FPMDVQTCIMQLESFGYTMNDLIFEWQ-EQGAVQVADGL-TLPQFILKEEKDLRYCTKHYNTGKF 235

  Fly   557 SCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRS 621
            :|::......|...||...::||.:::|..|:|:||:..:|.||||.:|:||:|...|.|:|.|:
Human   236 TCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA 300

  Fly   622 TLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGR---------------KRPLHNVVY--RP 669
            :||.||.:.|:::|..||:.|::::|||:..||:|.|               |.|:.|:..  ..
Human   301 SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEA 365

  Fly   670 GENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPMSSGTPAASSSVATPGTPRITDPE 734
            ||....      .|..|:   .| |...|...:|:.|.....::..|.|.|.          .||
Human   366 GEGRFN------FSAYGM---GP-ACLQAKDGISVKGANNSNTTNPPPAPSK----------SPE 410

  Fly   735 E 735
            |
Human   411 E 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	66/236 (28%)
		Neur_chan_memb	578..>682	CDD:280999	41/120 (34%)
GLRA1	NP_001139512.1	LIC	7..446	CDD:273305	129/456 (28%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	230..235		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..410		4/28 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614790at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020