Protein Alignment pHCl-1 and GABRB1

DIOPT Version :9

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_000803.2
• Gene: GABRB1 / 2560
• HGNCID: 4081
• Length: 474
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 91/338 - (26%)
• Similarity: 152/338 - (44%)
• Gaps: 64/338 - (18%)

  Fly   338 KEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASPD 402
            ||.:|.||  |.||.||.|     ||                     |...|:|. :.:.:||.|
Human    38 KETVDRLL--KGYDIRLRP-----DF---------------------GGPPVDVG-MRIDVASID 73

  Fly   403 ---ESSLKYEVEFLLNQQWNDPRLQY-GNKSHYDFLNALHHHDSIWTPDTYFI------MHG-DF 456
               |.::.|.:.....|.|.|.||.| |...:....|.:  .|.:|.|||||:      :|| ..
Human    74 MVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRV--ADQLWVPDTYFLNDKKSFVHGVTV 136

  Fly   457 KDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKN 521
            |:.:|.:|      .:||:.|.:|.....:|...|..:|.|:..|:..:||..|....|::.|..
Human   137 KNRMIRLH------PDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNG 195

  Fly   522 DEDTLR-----KSPSLTTLNAYLIKNQ---TTACDQNSWRGNYSCLQVELTFTRDRAYYFTTVFI 578
            .|..:.     :.|..:.::..::..:   ||        |.|..|.:.....|:..|:....::
Human   196 GEGAVTGVNKIELPQFSIVDYKMVSKKVEFTT--------GAYPRLSLSFRLKRNIGYFILQTYM 252

  Fly   579 PGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFI 643
            |..::...|:::||:.::|..|||.:|:||:|...|.|...|.|||.:..:.|::::...|..|:
Human   253 PSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFV 317

  Fly   644 YASLLEFVCVNYV 656
            :.:|||:..|||:
Human   318 FLALLEYAFVNYI 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	62/246 (25%)
		Neur_chan_memb	578..>682	CDD:280999	27/79 (34%)
GABRB1	NP_000803.2	LIC	9..472	CDD:273305	91/338 (27%)
		Agonist binding. /evidence=ECO:0000250	120..122		1/1 (100%)
		Agonist binding. /evidence=ECO:0000250	180..182		1/1 (100%)
		Allosteric effector binding. /evidence=ECO:0000250	290..311		6/20 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910