Protein Alignment pHCl-1 and GABRA6

DIOPT Version :10

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 130/472 - (27%)
• Similarity: 186/472 - (39%)
• Gaps: 124/472 - (26%)

  Fly   317 ALDKHPIHGIDWSKFDESSSDKEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRP 381
            ||.|..:.|   :.:.|:.|  .|||.|||  .||.||                         ||
Human    17 ALGKLEVEG---NFYSENVS--RILDNLLE--GYDNRL-------------------------RP 49

  Fly   382 HNRGTLT-VNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHHDSIWT 445
            ...|.:| |..::.:.|.....:..::|.::....|.|.|.||::|..:....||.| ....|||
Human    50 GFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNL-MVSKIWT 113

  Fly   446 PDTYF------IMHGDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFS 504
            |||:|      |.|.     :...:...||.:||||.|.||..:...|...|..||.|...|...
Human   114 PDTFFRNGKKSIAHN-----MTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLK 173

  Fly   505 MESISYEEAQIKYVWKN----DEDTLRKSPSL-------TTLNAYLIKNQTTACDQNSWRGNYSC 558
            ..|.:|.:::|.|.||.    ..:...:|.||       .|:::..||:.|         |.|..
Human   174 FGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNT---------GEYVI 229

  Fly   559 LQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTL 623
            :.|.....|...|:...::.|.|:.|..|.::||:...:||||.:.|:||:|...|.|...|.:|
Human   230 MTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSL 294

  Fly   624 PVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAVLSRIGVI 688
            |.||..|||:.:..||..|::::|:||..|||.              .|..||:
Human   295 PKVSYATAMDWFIAVCFAFVFSALIEFAAVNYF--------------TNLQTQK----------- 334

  Fly   689 LASPLASAAATPAMSMMGGATPM-------------------SSGTPAASSSVA----------- 723
             |...|..||.|.:::.....|:                   |...|..|||.|
Human   335 -AKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQ 398

  Fly   724 -TPGTPRITDPEEFFGG 739
             ||.||....|.  |||
Human   399 STPVTPPPLSPA--FGG 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	LIC	339..>662	CDD:455710	101/340 (30%)
		LGIC_TM	<948..975	CDD:476813
		TM4 helix	950..971	CDD:349850
GABRA6	NP_000802.2	LIC	5..440	CDD:455710	130/472 (28%)
		LGIC_ECD_GABAAR_A6	42..239	CDD:349840	60/236 (25%)
		Cys-loop	156..170	CDD:349840	5/13 (38%)