DRSC/TRiP Functional Genomics Resources

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Protein Alignment pHCl-1 and GABRA4

DIOPT Version :10

Sequence 1:NP_001261898.1 Gene:pHCl-1 / 39730 FlyBaseID:FBgn0264908 Length:978 Species:Drosophila melanogaster
Sequence 2:NP_000800.2 Gene:GABRA4 / 2557 HGNCID:4078 Length:554 Species:Homo sapiens


Alignment Length:651 Identity:156/651 - (23%)
Similarity:232/651 - (35%) Gaps:176/651 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   340 ILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLT-VNVNVLLLSLASPDE 403
            |||.||:  .||.||                         ||...|.:| |..::.:.|.....:
Human    51 ILDSLLD--GYDNRL-------------------------RPGFGGPVTEVKTDIYVTSFGPVSD 88

  Fly   404 SSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHHDSIWTPDTYF------IMHGDFKDPIIP 462
            ..::|.::....|.|.|.||:|........||.: ....:|||||:|      :.|.     :..
Human    89 VEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNM-MVTKVWTPDTFFRNGKKSVSHN-----MTA 147

  Fly   463 MHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVW-KNDEDTL 526
            .:...||.|||||.|.||..:...|...|..||.|...|.....|.:|.::::.|.| |..|.::
Human   148 PNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSV 212

  Fly   527 RKSPSLTTLNAYLIKNQTTACDQ-NSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFIT 590
            ......::|..|.:..||.:.:. .|..|.|..:.|.....|...|:....:||.|:.|..|.::
Human   213 EVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVS 277

  Fly   591 FWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNY 655
            ||:...:||||.:.|:||:|...|.|...|.:||.||..|||:.:..||..|::::|:||..|||
Human   278 FWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNY 342

  Fly   656 VGRKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPMSSGTPAASS 720
                  ..|:.....:...::               |.....|.|..                  
Human   343 ------FTNIQMEKAKRKTSK---------------PPQEVPAAPVQ------------------ 368

  Fly   721 SVATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTE 785
                    |...||                  |.:||..|....||  |:.:...|....|..||
Human   369 --------REKHPE------------------APLQNTNANLNMRK--RTNALVHSESDVGNRTE 405

  Fly   786 HIYEEPGGSTSGVTSTKVKFKDELKEEQPEEAESSTKLRRSVATSTPALVVRIE-------AEID 843
                  .|:.|..:||.|:             |||....||...|:|....|..       |...
Human   406 ------VGNHSSKSSTVVQ-------------ESSKGTPRSYLASSPNPFSRANAAETISAARAL 451

  Fly   844 PEAEDKPIQDMEMTERQLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKRQNAGAPNEIVA 908
            |.|....|:...|           ||:.:..|.|...|:....:.::.|.    ...||..::.|
Human   452 PSASPTSIRTGYM-----------PRKASVGSASTRHVFGSRLQRIKTTV----NTIGATGKLSA 501

  Fly   909 CTTCGGSNSPCTHSANNGCATETCFVQVRKKEPPHPIRVAKTIDVIARITFPTAYAIFLIFFFVH 973
            ...   .::|                      ||.....:| ||..|||.||..:..|.:.::|.
Human   502 TPP---PSAP----------------------PPSGSGTSK-IDKYARILFPVTFGAFNMVYWVV 540

  Fly   974 Y 974
            |
Human   541 Y 541

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pHCl-1NP_001261898.1 LIC 339..>662 CDD:455710 97/330 (29%)
LGIC_TM <948..975 CDD:476813 11/27 (41%)
TM4 helix 950..971 CDD:349850 8/20 (40%)
GABRA4NP_000800.2 LIC 13..541 CDD:455710 155/649 (24%)
LGIC_ECD_GABAAR_A4 57..255 CDD:349838 56/230 (24%)
Cys-loop 172..186 CDD:349838 5/13 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..381 9/89 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..435 15/56 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 452..471 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 495..515 5/44 (11%)

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