Protein Alignment pHCl-1 and GABRA3

DIOPT Version :9

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_000799.1
• Gene: GABRA3 / 2556
• HGNCID: 4077
• Length: 492
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 127/485 - (26%)
• Similarity: 196/485 - (40%)
• Gaps: 97/485 - (20%)

  Fly   300 CYLT-------------TASTAAATQSETGALDKHPIHGID---WSKFDESSSDK-----EILDL 343
            ||:|             |.....:.:.|.|...|..|.|:.   .....:.|:|.     .|||.
Human     9 CYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDR 73

  Fly   344 LLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASPDESSLKY 408
            ||:  .||.||.|.:.|                        ....|..::.:.|.....::.::|
Human    74 LLD--GYDNRLRPGLGD------------------------AVTEVKTDIYVTSFGPVSDTDMEY 112

  Fly   409 EVEFLLNQQWNDPRLQYGNKSHYDFLNALHHHDSIWTPDTYFIMHGDFKDPIIPM---HFALRIF 470
            .::....|.|:|.||::........||.| ....||||||:|  |...|.....|   :..||:.
Human   113 TIDVFFRQTWHDERLKFDGPMKILPLNNL-LASKIWTPDTFF--HNGKKSVAHNMTTPNKLLRLV 174

  Fly   471 RNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSL--- 532
            .|||:.|.||..:...|...|..||.|...|.....|.:|..|::.|.|     ||.|:.|:
Human   175 DNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSW-----TLGKNKSVEVA 234

  Fly   533 ---TTLNAY----------LIKNQTTACDQNSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILV 584
               :.||.|          :|::.|         |.|..:.......|...|:....::|.|:.|
Human   235 QDGSRLNQYDLLGHVVGTEIIRSST---------GEYVVMTTHFHLKRKIGYFVIQTYLPCIMTV 290

  Fly   585 TSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLE 649
            ..|.::|||...:||||.:.||||:|...|.|...|::||.|:..|||:.:..||..|::::|:|
Human   291 ILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIE 355

  Fly   650 FVCVNYV--------GRKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMG 706
            |..|||.        |:|.|....:.:.......::.....:.:|.  ..|:..|..|...::..
Human   356 FATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGT--TYPINLAKDTEFSTISK 418

  Fly   707 GATPMSSGTPAASSSVATPGTPRITD-PEE 735
            ||.|.:|.||   :.:|:|....:.| |.|
Human   419 GAAPSASSTP---TIIASPKATYVQDSPTE 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	62/251 (25%)
		Neur_chan_memb	578..>682	CDD:280999	37/111 (33%)
GABRA3	NP_000799.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..54		5/25 (20%)
		LIC	69..478	CDD:273305	116/425 (27%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	58/241 (24%)
		Cys-loop	191..205	CDD:349837	5/13 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910