Protein Alignment pHCl-1 and GABRA2

DIOPT Version :9

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001317619.1
• Gene: GABRA2 / 2555
• HGNCID: 4076
• Length: 511
• Species: Homo sapiens
• Alignment Length: 664
• Identity: 148/664 - (22%)
• Similarity: 236/664 - (35%)
• Gaps: 217/664 - (32%)

  Fly   332 DESSSD----KEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLT-VNV 391
            ||:.::    ..|||.||:  .||.||.|.:.|                         ::| |..
Human    33 DEAKNNITIFTRILDRLLD--GYDNRLRPGLGD-------------------------SITEVFT 70

  Fly   392 NVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHHDSIWTPDTYFIMHGDF 456
            |:.:.|.....::.::|.::....|:|.|.||::....:...||.| ....||||||:|  |...
Human    71 NIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNL-MASKIWTPDTFF--HNGK 132

  Fly   457 KDPIIPM---HFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYV 518
            |.....|   :..|||..:||:.|.||..:...|...|..||.|...|.....|.:|..:::.|:
Human   133 KSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYI 197

  Fly   519 WK-NDEDTLRKSPSLTTLNAYLIKNQTTACDQ-NSWRGNYSCLQVELTFTRDRAYYFTTVFIPGI 581
            |. |..|:::.:|..:.||.|.:..|:...:. .|..|.|:.:.......|...|:....::|.|
Human   198 WTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCI 262

  Fly   582 ILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYAS 646
            :.|..|.::|||...:||||.:.||||:|...|.|...|::||.|:..|||:.:..||..|::::
Human   263 MTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSA 327

  Fly   647 LLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPM 711
            |:||..|||..::
Human   328 LIEFATVNYFTKR---------------------------------------------------- 340

  Fly   712 SSGTPAASSSVATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSIS 776
                                        |..|.       |.:|.|.::.|||
Human   341 ----------------------------GWAWD-------GKSVVNDKSPSIK------------ 358

  Fly   777 PHPSGRPTEHIYEEPGGSTSGVTSTKVKFKDELKEEQPEEAESSTKL--RRSVATSTPALVVRIE 839
                              ..|:|.|....|..|:         ..||  .:.:|.|.|:|.
Human   359 ------------------AEGITLTYNSVKAILQ---------GAKLIWSKYIAFSWPSLF---- 392

  Fly   840 AEIDPEAEDKPIQDMEMTERQLSLPLKPPRRKAS---RSNSPASVYSDAFENVEATPGEKRQNAG 901
                   ::|.::.:|.....|:......:.|||   ::|:    |:.|..|.
Human   393 -------QEKTLEYLEKWMDCLTFKQSSKKEKASVMIQNNA----YAVAVANY------------ 434

  Fly   902 APNEIVACTTCGGSNSPCTHSANNGCATETCFVQVRKKEPPHPIRVAKT------IDVIARITFP 960
            |||.         |..|...:.:....|.    :..||....|....||      ||.::||.||
Human   435 APNL---------SKDPVLSTISKSATTP----EPNKKPENKPAEAKKTFNSVSKIDRMSRIVFP 486

  Fly   961 TAYAIFLIFFFVHY 974
            ..:..|.:.::..|
Human   487 VLFGTFNLVYWATY 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	62/233 (27%)
		Neur_chan_memb	578..>682	CDD:280999	34/103 (33%)
GABRA2	NP_001317619.1	LIC	25..500	CDD:273305	147/662 (22%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	60/231 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910