DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pHCl-1 and Glrb

DIOPT Version :9

Sequence 1:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_445748.1	Gene:	Glrb / 25456	RGDID:	2706	Length:	496	Species:	Rattus norvegicus

Alignment Length:	715	Identity:	157/715 - (21%)
Similarity:	260/715 - (36%)	Gaps:	245/715 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 YSQSISFYAASSVLLMLCYLTTASTAAATQSETGALDKH--PIH--GIDWSKFDESSSDKEILDL 343
            :|.::||:    :|:.|.:....|...:::...|...::  |..  ..|.::...:|: ..||:.
  Rat     3 FSLAVSFF----ILMSLLFEDACSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPPNST-SNILNR 62

  Fly   344 LLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRG-TLTVNVNVLLLSLASPDESSLK 407
            ||..  ||.|:                         ||:.:| .:.|.||:.:.|..|..|:::.
  Rat    63 LLVS--YDPRI-------------------------RPNFKGIPVDVVVNIFINSFGSIQETTMD 100

  Fly   408 YEVEFLLNQQWNDPRLQYGNKSHYDFLNAL----HHHDSIWTPDTYFI--MHGDFKDPIIPMHFA 466
            |.|...|.|:||||||:.  .|.:...:||    ..:..:|.||.:|.  ...:|.| :...:..
  Rat   101 YRVNIFLRQKWNDPRLKL--PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHD-VTQENIL 162

  Fly   467 LRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKN-DEDTLRKSP 530
            |.|||:|.:..:||..:.|||...|.:||.|..:|...:||..|....::::|:: |...|.|
  Rat   163 LFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEK-- 225

  Fly   531 SLTTLNAYLIKNQTTA---CDQ-NSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITF 591
              ..|..:.||.:...   |.: ....|.|:|::|..|..|...:|...|:.|.:::|..|:::|
  Rat   226 --IALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSF 288

  Fly   592 WLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYV 656
            |:..:|..|||.:|:.::|:..:......:.||.||.:.|::||...|:.|.:|||:|:..|..:
  Rat   289 WINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVM 353

  Fly   657 GRKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPMSSGTPAASSS 721
                 |:|          .:|:.|..:||          |.|..|....|.|        |..::
  Rat   354 -----LNN----------PKRVEAEKARI----------AKAEQADGKGGNA--------AKKNT 385

  Fly   722 VATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTEH 786
            |...|||                                                        .|
  Rat   386 VNGTGTP--------------------------------------------------------VH 394

  Fly   787 IYEEPGGSTSGVTSTKVKFKDELKEEQPEEAESSTKLRR---SVATSTPALVVRIEAEIDPEAED 848
            |      ||..|..|:.|          :...|.:.||.   |:..|.|
  Rat   395 I------STLQVGETRCK----------KVCTSKSDLRSNDFSIVGSLP---------------- 427

  Fly   849 KPIQDMEMTERQLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKRQNAGAPNEIVACTTCG 913
               :|.|::.                        .|.:              |.|.|:
  Rat   428 ---RDFELSN------------------------YDCY--------------GKPIEV------- 444

  Fly   914 GSNSPCTHSANNGCATETCFVQVRKKEPP--HPI--RVAKTIDVIARITFPTAYAIFLIFFFVHY 974
                      |||....    |.:.|:||  .|:  ..||.||:.||..||..:..|.:.::..|
  Rat   445 ----------NNGLGKP----QAKNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIY 495

Fly 975 974
Rat 496 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	66/239 (28%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	29/103 (28%)
Glrb	NP_445748.1	LIC	43..495	CDD:273305	148/669 (22%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	56/192 (29%)
		Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	247..253		1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614790at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110