DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-1 and glra4b

DIOPT Version :9

Sequence 1:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_001189440.1	Gene:	glra4b / 192125	ZFINID:	ZDB-GENE-020402-2	Length:	492	Species:	Danio rerio

Alignment Length:	690	Identity:	158/690 - (22%)
Similarity:	253/690 - (36%)	Gaps:	232/690 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 LLMLCYLTTASTAAATQSETGALDKHPIHGIDWSKFDESSSDKEILDLLLEK-KRYDKRLLPPVN 359
            ||::|::...........|.    |.|      |...:..|..:.||.|:.| ..||.|:
Zfish    12 LLLVCWMFEGVIRCVFSKEL----KSP------SVRTKPMSPSDFLDKLMGKTSGYDARI----- 61

  Fly   360 DEDFCCGLQSPDMATNQNARRPHNRG-TLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRL 423
                                ||:.:| .:.|..|:.:.|..|..|:::.|.:...|.||||||||
Zfish    62 --------------------RPNFKGPPVNVTCNIFINSFGSITETTMDYRLNVFLRQQWNDPRL 106

  Fly   424 QYGNKSHYDFLNALHHH--DSIWTPDTYFIMH--GDFKDPIIPMHFALRIFRNGTITYAMRRHLI 484
            .|  |.:.|....|...  ||||.||.:|...  .:|.: :...:..||||:||.:.|::|..||
Zfish   107 AY--KEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHE-VTTDNKLLRIFQNGNVLYSIRLTLI 168

  Fly   485 LSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLTTLNAYLIKNQTTA--C 547
            |||...|..||.|...|:..:||..|....:.:.|. ||..::.:..| .|..:::|.:...  |
Zfish   169 LSCPMDLKNFPMDTQTCTMQLESFGYTMNDLIFQWL-DEGPVQVADDL-MLPQFVLKEEKDLGYC 231

  Fly   548 DQNSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNF 612
            .::...|.::|::|:....|...||...::||.::.|..|:::||:..:|.||||.:|:||:|..
Zfish   232 TKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLTVILSWVSFWINMDAAPARVGLGITTVLTM 296

  Fly   613 FTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQR 677
            .|.|:|.|::||.||.:.|:::|..||:.|::|:|||:..||:|.|:       |:
Zfish   297 TTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQ-------YK--------- 345

  Fly   678 LPAVLSRIGVILASPLASAAATPAMSMMGGATPMSSGTPAASSSVATPGTPRITDPEEFFGGGMR 742
                                                                     |||
Zfish   346 ---------------------------------------------------------EFF----- 348

  Fly   743 WQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTEHIYEEPGGSTSGVTSTKVKFKD 807
                            |.|...|:..|:.:.|                   ..:|...||.|
Zfish   349 ----------------RLRRKLRQEQRNRAAS-------------------GQAGAAETKNK--- 375

  Fly   808 ELKEEQPEEAESSTKLRRSVATSTPALVVRIEAEIDPEAEDKPIQDMEMTERQLSLPLKPPRRKA 872
                            ..:|...||:                     ...:||.|        ..
Zfish   376 ----------------SNNVTGGTPS---------------------RNAQRQCS--------AC 395

  Fly   873 SRSNSPASVYSDAFENVEATPGEKRQNAGAPNEIVACTTCGGSNSPCTHSAN--NGCATETCFVQ 935
            :|....||...|.:     .||            ....|....:.|.:.:|.  .|.........
Zfish   396 AREEQLASQNQDLY-----FPG------------FGIDTSLSGDGPLSEAAAMFAGLPPGHALFD 443

  Fly   936 VRKKEPPHPIRVAKTIDVIARITFPTAYAIFLIFFFVHYK 975
            :|::.    :..||.||.|:|..||.::.:|.:|::|.||
Zfish   444 IRRRF----VEQAKRIDTISRAVFPLSFLVFNVFYWVTYK 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	68/235 (29%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	37/103 (36%)
glra4b	NP_001189440.1	LIC	5..478	CDD:273305	156/687 (23%)
		Neur_chan_LBD	47..253	CDD:280998	69/235 (29%)
		Neur_chan_memb	260..475	CDD:280999	76/396 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614790at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.110