Protein Alignment pHCl-1 and glra4b

DIOPT Version :10

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: XP_073805842.1
• Gene: glra4b / 192125
• ZFINID: ZDB-GENE-020402-2
• Length: 575
• Species: Danio rerio
• Alignment Length: 684
• Identity: 158/684 - (23%)
• Similarity: 257/684 - (37%)
• Gaps: 227/684 - (33%)

  Fly   330 KFDESSSDKEILD----------LLLE------------KKRYDKRL------LPPVNDEDFCCG 366
            ||...:.:|::|:          :|||            :..:.|.|      ..|::..||...
Zfish    68 KFSHGTPEKQLLNSERMFSVIWRILLELLLVCWMFEGVIRCVFSKELKSPSVRTKPMSPSDFLDK 132

  Fly   367 LQSPDMATNQNAR-RPHNRG-TLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKS 429
            |..  ..:..:|| ||:.:| .:.|..|:.:.|..|..|:::.|.:...|.||||||||.|  |.
Zfish   133 LMG--KTSGYDARIRPNFKGPPVNVTCNIFINSFGSITETTMDYRLNVFLRQQWNDPRLAY--KE 193

  Fly   430 HYDFLNALHHH--DSIWTPDTYFIMH--GDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGS 490
            :.|....|...  ||||.||.:|...  .:|.: :...:..||||:||.:.|::|..|||||...
Zfish   194 YPDDSLDLDPSMLDSIWKPDLFFANEKGANFHE-VTTDNKLLRIFQNGNVLYSIRLTLILSCPMD 257

  Fly   491 LHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLTTLNAYLIKNQTTA--CDQNSWR 553
            |..||.|...|:..:||..|....:.:.|. ||..::.:..| .|..:::|.:...  |.::...
Zfish   258 LKNFPMDTQTCTMQLESFGYTMNDLIFQWL-DEGPVQVADDL-MLPQFVLKEEKDLGYCTKHYNT 320

  Fly   554 GNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNG 618
            |.::|::|:....|...||...::||.::.|..|:::||:..:|.||||.:|:||:|...|.|:|
Zfish   321 GKFTCIEVKFHLERQMGYYLIQMYIPSLLTVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSG 385

  Fly   619 FRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAVLS 683
            .|::||.||.:.|:::|..||:.|::|:|||:..||:|.|:       |:
Zfish   386 SRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQ-------YK--------------- 428

  Fly   684 RIGVILASPLASAAATPAMSMMGGATPMSSGTPAASSSVATPGTPRITDPEEFFGGGMRWQEAHG 748
                                                               |||
Zfish   429 ---------------------------------------------------EFF----------- 431

  Fly   749 GIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTEHIYEEPGGSTSGVTSTKVKFKDELKEEQ 813
                      |.|...|:..|:.:.|                   ..:|...||.|
Zfish   432 ----------RLRRKLRQEQRNRAAS-------------------GQAGAAETKNK--------- 458

  Fly   814 PEEAESSTKLRRSVATSTPALVVRIEAEIDPEAEDKPIQDMEMTERQLSLPLKPPRRKASRSNSP 878
                      ..:|...||:                     ...:||.|        ..:|....
Zfish   459 ----------SNNVTGGTPS---------------------RNAQRQCS--------ACAREEQL 484

  Fly   879 ASVYSDAFENVEATPGEKRQNAGAPNEIVACTTCGGSNSPCTHSAN--NGCATETCFVQVRKKEP 941
            ||...|.:     .||            ....|....:.|.:.:|.  .|.........:|::.
Zfish   485 ASQNQDLY-----FPG------------FGIDTSLSGDGPLSEAAAMFAGLPPGHALFDIRRRF- 531

  Fly   942 PHPIRVAKTIDVIARITFPTAYAIFLIFFFVHYK 975
               :..||.||.|:|..||.::.:|.:|::|.||
Zfish   532 ---VEQAKRIDTISRAVFPLSFLVFNVFYWVTYK 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	LIC	339..>662	CDD:455710	112/358 (31%)
		LGIC_TM	<948..975	CDD:476813	11/26 (42%)
		TM4 helix	950..971	CDD:349850	8/20 (40%)
glra4b	XP_073805842.1	None