DRSC/TRiP Functional Genomics Resources

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Protein Alignment pHCl-1 and lgc-54

DIOPT Version :10

Sequence 1:NP_001261898.1 Gene:pHCl-1 / 39730 FlyBaseID:FBgn0264908 Length:978 Species:Drosophila melanogaster
Sequence 2:NP_001343648.1 Gene:lgc-54 / 188525 WormBaseID:WBGene00020528 Length:493 Species:Caenorhabditis elegans


Alignment Length:362 Identity:96/362 - (26%)
Similarity:165/362 - (45%) Gaps:63/362 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   322 PIHGIDWSKFDESSSDKEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGT 386
            ||...||...||.::| .|..|:|      :||.    |:::           |:|. .|.....
 Worm    34 PIENYDWMHCDEPAND-TISQLVL------RRLF----DDNY-----------NKNT-VPLKTSA 75

  Fly   387 LTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHH-------HDSIW 444
            ..|:|...:.::|...|.|..:.::.|.:|.|:||||::.:     ..|.|.:       .:.:|
 Worm    76 TVVSVEFGIQNIAQVSEISASFTLDLLFSQIWHDPRLRFDH-----LTNCLQNLTLGYSMVEKLW 135

  Fly   445 TPDTYFI------MHGDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSF 503
            ||:..|:      :|......|.     |.|:.|||:....|..:...|...|.:||.|...|..
 Worm   136 TPNVCFVNSKKTEIHSSPTPNIF-----LMIYPNGTVWVNYRLQVQSPCMVDLVLFPMDIMNCEL 195

  Fly   504 SMESISYEEAQIKYVWKNDED--TLRKSPSLTTLNAYLIKNQTTACDQNSWR---GNYSCLQVEL 563
            .:||.:|..|::|..|:..:.  ::.|| .|:....|.:  |.|   :||:.   |.:..|.|.|
 Worm   196 IIESYAYNAAKVKLNWREWQPVFSIAKS-KLSDFTLYGL--QWT---KNSFEYAAGQWDQLTVSL 254

  Fly   564 TFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSN 628
            ||:|...:|...::||....|..||::||::..|:|||:.:||::::............||.|..
 Worm   255 TFSRAYGFYILQMYIPTYSSVFLSFVSFWIDLKALPARITLGVSSLMALTFQYGNVAKNLPRVGY 319

  Fly   629 LTAMNVWDGVCMCFIYASLLE--FVCV----NYVGRK 659
            :.:::|:..:...||:.:::|  |||.    |.:.||
 Worm   320 VKSIDVYMVLTTAFIFLTMIEVAFVCYLDSENNLRRK 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pHCl-1NP_001261898.1 LIC 339..>662 CDD:455710 89/345 (26%)
LGIC_TM <948..975 CDD:476813
TM4 helix 950..971 CDD:349850
lgc-54NP_001343648.1 LIC 55..474 CDD:455710 87/340 (26%)
LGIC_ECD_GABAAR 76..258 CDD:349791 52/197 (26%)
Cys-loop 179..193 CDD:349791 5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

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