DRSC/TRiP Functional Genomics Resources

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Protein Alignment pHCl-1 and Htr3a

DIOPT Version :10

Sequence 1:NP_001261898.1 Gene:pHCl-1 / 39730 FlyBaseID:FBgn0264908 Length:978 Species:Drosophila melanogaster
Sequence 2:NP_038589.2 Gene:Htr3a / 15561 MGIID:96282 Length:489 Species:Mus musculus


Alignment Length:407 Identity:92/407 - (22%)
Similarity:156/407 - (38%) Gaps:77/407 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   372 MATNQNARRPHN--RGTLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFL 434
            :|..:...||..  |...||:::|::.::.:.||.:..........|.|.|..||: ....:|.:
Mouse    47 LANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQW-TPEDFDNV 110

  Fly   435 NALH-HHDSIWTPDTYFIMHGDF----KDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIF 494
            ..|. ..||||.||   |:..:|    |.|.||..:   :...|.:.......|:.:|...::.|
Mouse   111 TKLSIPTDSIWVPD---ILINEFVDVGKSPNIPYVY---VHHRGEVQNYKPLQLVTACSLDIYNF 169

  Fly   495 PFDDPKCSFSMESISYEEAQIKY-VWKNDEDTLRKSPSLTTLNAYLIKNQTTACDQNSWR----- 553
            |||...||.:..|..:....|.. :|::.|: :|...|:             ..:|..|.     
Mouse   170 PFDVQNCSLTFTSWLHTIQDINITLWRSPEE-VRSDKSI-------------FINQGEWELLEVF 220

  Fly   554 -----------GNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVT 607
                       .:|:.::..:...|...:|..::.:|.|.|:....:.|.|..:: ..||...:|
Mouse   221 PQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDS-GERVSFKIT 284

  Fly   608 TMLNFFTTSNGFRSTLPVVSNLTAM-NVWDGVCMCFIYASLLEFVCVNYVGRKRPL--------- 662
            .:|.:.........|||..:..|.: .|:..|||..:..||.|.:.:..:..|:.|         
Mouse   285 LLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLR 349

  Fly   663 HNVVYR------PGENPVTQRLPAVLSRIGVILASPLASAAATPAM----SMMGG-----ATPMS 712
            |.|:.|      .||.|:..|.||...   .......:.:...|||    |.:||     .||..
Mouse   350 HLVLDRIAWILCLGEQPMAHRPPATFQ---ANKTDDCSGSDLLPAMGNHCSHVGGPQDLEKTPRG 411

  Fly   713 SGT---PAASSSVATPG 726
            .|:   |...:|:|..|
Mouse   412 RGSPLPPPREASLAVRG 428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pHCl-1NP_001261898.1 LIC 339..>662 CDD:455710 69/314 (22%)
LGIC_TM <948..975 CDD:476813
TM4 helix 950..971 CDD:349850
Htr3aNP_038589.2 LIC 5..483 CDD:273305 92/407 (23%)
HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000250|UniProtKB:P46098 425..461 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

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