DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pHCl-1 and Glrb

DIOPT Version :9

Sequence 1:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	XP_036018791.1	Gene:	Glrb / 14658	MGIID:	95751	Length:	530	Species:	Mus musculus

Alignment Length:	695	Identity:	160/695 - (23%)
Similarity:	263/695 - (37%)	Gaps:	218/695 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 CYLTTASTAAATQSETGALDKHPIHGIDWSKFDESSSDKEILDLLLEKKRYDKRLLPPVNDEDFC 364
            |:||:.|.....|:...:..:.|   .|.::...:|: ..||:.||..  ||.|:
Mouse    33 CHLTSDSELLGLQACHHSCQQSP---EDLARVPPNST-SNILNRLLVS--YDPRI---------- 81

  Fly   365 CGLQSPDMATNQNARRPHNRG-TLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNK 428
                           ||:.:| .:.|.||:.:.|..|..|:::.|.|...|.|:||||||:.  .
Mouse    82 ---------------RPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKL--P 129

  Fly   429 SHYDFLNAL----HHHDSIWTPDTYFI--MHGDFKDPIIPMHFALRIFRNGTITYAMRRHLILSC 487
            |.:...:||    ..:..:|.||.:|.  ...:|.| :...:..|.|||:|.:..:||..:.|||
Mouse   130 SDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHD-VTQENILLFIFRDGDVLVSMRLSITLSC 193

  Fly   488 QGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKN-DEDTLRKSPSLTTLNAYLIKNQTTA---CD 548
            ...|.:||.|..:|...:||..|....::::|:: |...|.|    ..|..:.||.:...   |.
Mouse   194 PLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEK----IALPQFDIKKEDIEYGNCT 254

  Fly   549 Q-NSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNF 612
            : ....|.|:|::|..|..|...:|...|:.|.:::|..|:::||:..:|..|||.:|:.::|:.
Mouse   255 KYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSL 319

  Fly   613 FTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQR 677
            .:......:.||.||.:.|::||...|:.|.:|||:|:..|..:     |:|          .:|
Mouse   320 ASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVM-----LNN----------PKR 369

  Fly   678 LPAVLSRIGVILASPLASAAATPAMSMMGGATPMSSGTPAASSSVATPGTP-RITDPEEFFGGGM 741
            :.|..:||          |.|..|....|.|        |..::|...||| .|:..:|.   .|
Mouse   370 VEAEKARI----------AKAEQADGKGGNA--------AKKNTVNGTGTPVHISTLQEL---PM 413

  Fly   742 RWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTEHIYEEPGGSTSGVTSTKVKFK 806
            ..|:                             |:....|.||:.:       |:.|..|:.|
Mouse   414 VCQQ-----------------------------ITYQLDGWPTDTL-------TTQVGETRCK-- 440

  Fly   807 DELKEEQPEEAESSTKLRR---SVATSTPALVVRIEAEIDPEAEDKPIQDMEMTERQLSLPLKPP 868
                    :...|.:.||.   |:..|.|                   :|.|::.
Mouse   441 --------KVCTSKSDLRSNDFSIVGSLP-------------------RDFELSN---------- 468

  Fly   869 RRKASRSNSPASVYSDAFENVEATPGEKRQNAGAPNEIVACTTCGGSNSPCTHSANNGCATETCF 933
                          .|.:              |.|.|:                 |||....
Mouse   469 --------------YDCY--------------GKPIEV-----------------NNGLGKP--- 485

  Fly   934 VQVRKKEPP--HPI--RVAKTIDVIARITFPTAYAIFLIFFFVHY 974
             |.:.|:||  .|:  ..||.||:.||..||..:..|.:.::..|
Mouse   486 -QAKNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIY 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	66/239 (28%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	29/103 (28%)
Glrb	XP_036018791.1	LIC	64..529	CDD:273305	152/659 (23%)
Glrb	XP_036018791.1	LGIC_ECD_GlyR_beta	89..275	CDD:349811	56/192 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100