DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-1 and Glra1

DIOPT Version :9

Sequence 1:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_001277750.1	Gene:	Glra1 / 14654	MGIID:	95747	Length:	457	Species:	Mus musculus

Alignment Length:	387	Identity:	115/387 - (29%)
Similarity:	191/387 - (49%)	Gaps:	60/387 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 YS-QSISFYAASSVLLMLCYLTTASTAAATQSETGALDKHPIHGIDWSKFDESSSDKEILDLLLE 346
            || .::.||...:::..       |.||:.::|.......|:            |..:.||.|:.
Mouse     2 YSFNTLRFYLWETIVFF-------SLAASKEAEAARSAPKPM------------SPSDFLDKLMG 47

  Fly   347 K-KRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRG-TLTVNVNVLLLSLASPDESSLKYE 409
            : ..||.|:                         ||:.:| .:.|:.|:.:.|..|..|:::.|.
Mouse    48 RTSGYDARI-------------------------RPNFKGPPVNVSCNIFINSFGSIAETTMDYR 87

  Fly   410 VEFLLNQQWNDPRLQYGNKSHYDFL----NALHHHDSIWTPDTYFIMH-GDFKDPIIPMHFALRI 469
            |...|.||||||||.| |:...|.|    :.|   ||||.||.:|... |.....|...:..|||
Mouse    88 VNIFLRQQWNDPRLAY-NEYPDDSLDLDPSML---DSIWKPDLFFANEKGAHFHEITTDNKLLRI 148

  Fly   470 FRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLTT 534
            .|||.:.|::|..|.|:|...|..||.|...|...:||..|....:.:.|: ::..::.:..| |
Mouse   149 SRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQ-EQGAVQVADGL-T 211

  Fly   535 LNAYLIKNQTTA--CDQNSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNA 597
            |..:::|.:...  |.::...|.::|::......|...||...::||.:::|..|:|:||:..:|
Mouse   212 LPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDA 276

  Fly   598 VPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRK 659
            .||||.:|:||:|...|.|:|.|::||.||.:.|:::|..||:.|::::|||:..||:|.|:
Mouse   277 APARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQ 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	66/236 (28%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	36/82 (44%)
Glra1	NP_001277750.1	LIC	7..446	CDD:273305	113/382 (30%)
		Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	230..235		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614790at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110