Protein Alignment pHCl-1 and pHCl-1

DIOPT Version :10

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: XP_061508178.1
• Gene: pHCl-1 / 1276287
• VectorBaseID: AGAMI1_005729
• Length: 883
• Species: Anopheles gambiae
• Alignment Length: 834
• Identity: 446/834 - (53%)
• Similarity: 526/834 - (63%)
• Gaps: 167/834 - (20%)

  Fly   187 RRQPDPAAHPASITKLSAISLHFHALAALAKTLQKHEDLSPVQDRQ--PLAYRAWQEHPYAETQM 249
            |....|.||..:.:...|     |..:..:.|:::|:|.....|.|  ||.:||.::    .||.
Mosquito   175 RSAASPMAHTVTPSSRPA-----HGSSTSSSTIRRHDDEPCRSDGQPVPLGHRAHRQ----PTQF 230

  Fly   250 PATMSAAIIANVGATAAATSAAAFQYLGQHYKHYSQSISFYAASSVLLMLCYLTTASTAAATQSE 314
            .|   .::..:|.|:...:..|:..:|.:|      |:..||||||||.|||||..:.|:.|
Mosquito   231 HA---PSVQRDVAASPTTSRPASSHHLVRH------SLCLYAASSVLLALCYLTIPTVASDT--- 283

  Fly   315 TGALDKHPIHGIDWSKFDESSSDKEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATN---- 375
                 .|||.|  ..:|.|..|||||||.||:..||||||||||:|.|||||:.:|:||.:
Mosquito   284 -----AHPIRG--RVRFAEGKSDKEILDHLLKNSRYDKRLLPPVDDADFCCGMHTPEMAKHIPDM 341

  Fly   376 QNARRPHNRGTLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHH 440
            :...||.|||||||||:||||||||||||||||||||||.|||.||||:|.|:|.|::|||:|||
Mosquito   342 RVPGRPQNRGTLTVNVSVLLLSLASPDESSLKYEVEFLLQQQWFDPRLRYANQSQYEYLNAIHHH 406

  Fly   441 DSIWTPDTYFIMHGDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSM 505
            :.||.||||||||||||||||||||||||:|||||.|.|||||||||||.|:|||||||.|||::
Mosquito   407 EDIWLPDTYFIMHGDFKDPIIPMHFALRIYRNGTINYLMRRHLILSCQGRLNIFPFDDPLCSFAL 471

  Fly   506 ESISYEEAQIKYVWKNDEDTLRKSPSLTTLNAYLIKNQTTACD-QNSWR---------------- 553
            ||||||::.|.||||||||||||||||||||||||:|||.||. :.|||
Mosquito   472 ESISYEQSAITYVWKNDEDTLRKSPSLTTLNAYLIQNQTIACPIKASWRAEGQTLSVEDEEFLCN 536

  Fly   554 ---------GNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVTTM 609
                     ||||||:|:|.||||||:||||||||||||||||||||||||||||||.|||||||
Mosquito   537 LCQRRFEEQGNYSCLKVDLIFTRDRAFYFTTVFIPGIILVTSSFITFWLEWNAVPARSMIGVTTM 601

  Fly   610 LNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPV 674
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   602 LNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPV 666

  Fly   675 TQRLPAVLSRIGVILASPLASAAATPAMSM-MGGATPMSSGTPAASSSVATPGTPRITDPEEFFG 738
            ||||||||||||:||||||:|......:.. ...|......|||.::|||
Mosquito   667 TQRLPAVLSRIGIILASPLSSRLLPETIDREFHTAIAAEKTTPATAASVA--------------- 716

  Fly   739 GGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTEHIYEEPGGSTSGVTSTKV 803
                                 |.:..|.|...|..:::|..:..|.
Mosquito   717 ---------------------AATAGRLAQTPPHRTVAPAATVPPL------------------- 741

  Fly   804 KFKDELKEEQPEEAESSTKLRRSVATSTPALVVRI-EAEIDPEAED--------KPIQDMEMTER 859
                           ::..:...:|::.||..|.: |..:..:|..        :|..:.::.|.
Mosquito   742 ---------------ATAPIAPPIASAAPAAAVLLCEEGLATDASSAGPGLTRRRPTVETKLNEA 791

  Fly   860 QLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKRQNAGAPNEIVACTTCGGSNSPCTHSAN 924
            .|                           :|.:.|.|::.:|.||||||||:|.|..||||||||
Mosquito   792 GL---------------------------METSFGVKKRESGGPNEIVACTSCAGGTSPCTHSAN 829

  Fly   925 NGCATETCFVQVRKKEPPHPIRVAKTIDVIARITFPTAYAIFLIFFFVHYKGFS 978
            ||||||||||||||||||||||||||||||||||||:|||:||||||:||||||
Mosquito   830 NGCATETCFVQVRKKEPPHPIRVAKTIDVIARITFPSAYAVFLIFFFIHYKGFS 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	LIC	339..>662	CDD:455710	270/352 (77%)
		LGIC_TM	<948..975	CDD:476813	23/26 (88%)
		TM4 helix	950..971	CDD:349850	18/20 (90%)
pHCl-1	XP_061508178.1	None