Protein Alignment pHCl-1 and Gabra5

DIOPT Version :9

• Sequence 1: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001349090.1
• Gene: Gabra5 / 110886
• MGIID: 95617
• Length: 463
• Species: Mus musculus
• Alignment Length: 569
• Identity: 124/569 - (21%)
• Similarity: 204/569 - (35%)
• Gaps: 158/569 - (27%)

  Fly   287 ISFYAASSVLLMLCY-LTTASTAAATQSETGALDKHPIHGIDWSKFDESSSD----KEILDLLLE 346
            :|.:..:..||:.|. :|.:|....:|..|.::.            ||::.:    ..|||.||:
Mouse     6 LSRFIMTQTLLVFCISMTLSSHFGFSQMPTSSVQ------------DETNDNITIFTRILDGLLD 58

  Fly   347 KKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASPDESSLKYEVE 411
              .||.||.|.:.:.                        ...|..::.:.|.....::.::|.::
Mouse    59 --GYDNRLRPGLGER------------------------ITQVRTDIYVTSFGPVSDTEMEYTID 97

  Fly   412 FLLNQQWNDPRLQY-GNKSHYDFLNALHHHDSIWTPDTYF------IMHGDFKDPIIPMHFALRI 469
            ....|.|.|.||:: |........|.|  ...||||||:|      |.|.     :...:..||:
Mouse    98 VFFRQSWKDERLRFKGPMQRLPLNNLL--ASKIWTPDTFFHNGKKSIAHN-----MTTPNKLLRL 155

  Fly   470 FRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKND--------EDTL 526
            ..:||:.|.||..:...|...|..||.|...|.....|.:|..:::.|||.|.        ||..
Mouse   156 EDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGS 220

  Fly   527 RKSPSLTTLNAYLIKNQTTACDQ-NSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFIT 590
            |       ||.|.:..||...:. ::..|.|:.:.......|...|:....::|.|:.|..|.::
Mouse   221 R-------LNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVS 278

  Fly   591 FWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNY 655
            |||...:||||.:.||||:|...|.|...|::||.|:..|||:.:..||..|::::|:||..|||
Mouse   279 FWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY 343

  Fly   656 VGRKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPMSSGTPAASS 720
            ..::
Mouse   344 FTKR------------------------------------------------------------- 347

  Fly   721 SVATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTE 785
                               |..| :....:..|.::......|..|:..:.:|....||...|.
Mouse   348 -------------------GWAW-DGKKALEAAKIKKKERELILNKSTNAFTTGKLTHPPNIPK- 391

  Fly   786 HIYEEPGGSTSGVTSTKVKFKDELKEEQPEEAESSTKLRRSVATSTPAL 834
               |:|...|:...:..:|..:|...|..:...|.:|:.:......|.|
Mouse   392 ---EQPPAGTANAPTVSIKASEEKTAESKKTYNSISKIDKMSRIVFPIL 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	59/243 (24%)
		Neur_chan_memb	578..>682	CDD:280999	34/103 (33%)
Gabra5	NP_001349090.1	LIC	15..449	CDD:273305	123/560 (22%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	54/237 (23%)
		Cys-loop	173..187	CDD:349839	5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..408		4/24 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910