DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LHCGR and rk

DIOPT Version :9

Sequence 1:NP_000224.2 Gene:LHCGR / 3973 HGNCID:6585 Length:699 Species:Homo sapiens
Sequence 2:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster


Alignment Length:707 Identity:233/707 - (32%)
Similarity:365/707 - (51%) Gaps:83/707 - (11%)


- Green bases have known domain annotations that are detailed below.


Human     3 QRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPT---AGLTRLSLAYLPVKVI 64
            :..:||::|:|...|...||..|.:....:..: :....||....|   ..:..|.:...|:..|
  Fly   344 KNLTALKVLELDDNLISSLPEGLSKLSQLQELS-ITSNRLRWINDTELPRSMQMLDMRANPLSTI 407

Human    65 PSQAFRGLNEVIKIEISQIDSLERIEANAFDNL--LNLSEILIQNTKNLRYIEPGAFINLPRLKY 127
            ...||||::::.|:.:|.:.:|     .:|..|  .:..|||..:...::.:........||||.
  Fly   408 SPGAFRGMSKLRKLILSDVRTL-----RSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKS 467

Human   128 LSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSH 192
            |.:....:::.|:::   |.....:|::..| .|..|.|..|.|:...:..|..| |..:.:...
  Fly   468 LELKTNSLKRIPNLS---SCRDLRLLDLSSN-QIEKIQGKPFNGLKQLNDLLLSY-NRIKALPQD 527

Human   193 AFNG-TTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSL 256
            ||.| ..|..|:|:.| .:..:|..||.|.|..:.|::.:.....||..||.::..|...::..|
  Fly   528 AFQGIPKLQLLDLEGN-EISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKL 591

Human   257 KKLPSRETFVNLLEATLTYPSHCCAFRNLP---TKEQNFSHSISE-------------------- 298
            ::.|..:||..:....|:|..|||||  ||   ...|..:..:.|                    
  Fly   592 REFPPPDTFPRIQTLILSYAYHCCAF--LPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMM 654

Human   299 -------NFSKQCES-------TVRKVNNKTLYS------------SMLAESELSGWDYEYGF-- 335
                   |.|||..:       |....|.:.|.:            ....|.::||....|||  
  Fly   655 NIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGT 719

Human   336 ----------CLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYK 390
                      ..|.:.:|.|.|..|.||.|:..:..||..:|::.:|:::||.||:||||.||.|
  Fly   720 GLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSK 784

Human   391 LTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVY 455
            :.|||||:|||:.|||.||:||.::|.||:.|.|::...||.||....|..:||..|.:||||||
  Fly   785 MDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVY 849

Human   456 TLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVE 520
            ||.||||||.:.||:||||:::|.|:.|..||..||:|:.::|::||||||:|.|.::|.|.:..
  Fly   850 TLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETT 914

Human   521 T-TLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAP 584
            | ..|..|:::::.:|..||..:..||:|:|:|:|..:...|| |::|||:||:|:||||.|.:|
  Fly   915 TGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTN-DSRIAKRMALLVFTDFLCWSP 978

Human   585 ISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKF 641
            |:||:|:|.|.:.||::..:|:..|...|:|||.|||||||.||.|::|...|...|
  Fly   979 IAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHF 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LHCGRNP_000224.2 leucine-rich repeat 51..74 CDD:275380 7/22 (32%)
LRR_5 62..198 CDD:290045 33/138 (24%)
leucine-rich repeat 75..99 CDD:275380 5/25 (20%)
LRR 1 96..115 4/20 (20%)
leucine-rich repeat 100..124 CDD:275380 3/23 (13%)
LRR 2 124..145 5/20 (25%)
leucine-rich repeat 125..150 CDD:275380 5/24 (21%)
LRR 3 149..171 6/21 (29%)
leucine-rich repeat 151..174 CDD:275380 7/22 (32%)
leucine-rich repeat 175..198 CDD:275380 6/23 (26%)
LRR 4 175..196 5/20 (25%)
LRR 5 198..220 7/21 (33%)
leucine-rich repeat 199..223 CDD:275380 8/23 (35%)
LRR 6 223..244 5/20 (25%)
leucine-rich repeat 224..244 CDD:275380 5/19 (26%)
7tm_1 376..623 CDD:278431 122/247 (49%)
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380
LRR_RI 180..>383 CDD:238064 8/39 (21%)
leucine-rich repeat 183..204 CDD:275380
LRR_8 203..263 CDD:290566
leucine-rich repeat 205..228 CDD:275380
leucine-rich repeat 229..252 CDD:275380
LRR_8 252..311 CDD:290566
leucine-rich repeat 253..276 CDD:275380
leucine-rich repeat 277..300 CDD:275380
LRR_8 299..359 CDD:290566 4/14 (29%)
leucine-rich repeat 301..324 CDD:275380
leucine-rich repeat 325..348 CDD:275380 0/3 (0%)
LRR_RI 327..567 CDD:238064 56/234 (24%)
leucine-rich repeat 349..371 CDD:275380 7/21 (33%)
LRR_8 370..425 CDD:290566 11/55 (20%)
leucine-rich repeat 372..393 CDD:275380 3/21 (14%)
leucine-rich repeat 394..415 CDD:275380 6/20 (30%)
leucine-rich repeat 418..486 CDD:275380 15/75 (20%)
leucine-rich repeat 441..464 CDD:275378 3/22 (14%)
LRR_8 487..545 CDD:290566 17/60 (28%)
leucine-rich repeat 487..510 CDD:275380 7/23 (30%)
leucine-rich repeat 511..534 CDD:275380 6/23 (26%)
LRR_8 533..589 CDD:290566 15/56 (27%)
leucine-rich repeat 535..558 CDD:275380 8/23 (35%)
leucine-rich repeat 559..580 CDD:275380 5/20 (25%)
7tm_4 764..>892 CDD:304433 68/127 (54%)
7tm_1 770..1017 CDD:278431 122/247 (49%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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