DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment meru and Rassf10

DIOPT Version :9

Sequence 1:	NP_001246779.1	Gene:	meru / 39727	FlyBaseID:	FBgn0052150	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_780488.2	Gene:	Rassf10 / 78748	MGIID:	1925998	Length:	508	Species:	Mus musculus

Alignment Length:	451	Identity:	91/451 - (20%)
Similarity:	153/451 - (33%)	Gaps:	129/451 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 VEQGHKEIPIWMDDGEARYVSGVTNKTTCDDIIKALIDD----ELRNGNGFYCGNNPKDGGQRKT 178
            ::...|:|.:|:.. |.:.|||::.:|||.|:::.|::|    ..|...|...|......||.:.
Mouse     1 MDPSEKKISVWICQ-EEKLVSGLSRRTTCSDVVRVLLEDGCRRRCRQRRGQRRGLTEDPSGQLEL 64

  Fly   179 AAA--SRDYSD---------------YIITESWGGIERCYDGNMAILPVWRAWSRVHNELRISLK 226
            ...  ..|..|               |.|.|.|.|.||.......||.:|.||......:|..|.
Mouse    65 PEPPDENDEDDDDAMPPGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWTAWGDEQENVRFVLV 129

  Fly   227 HRDSFRDPLAMQLVPHSQSATGFSMYKWLKKLLHLKKGKKTPP-------KPTKTPPKVPNKLKE 284
            ..::        .:|::...:..:.....::...|.:|....|       |..:...|...||.:
Mouse   130 RSEA--------SLPNAGPRSAEARVVLSRERPCLARGAPARPSLALTQEKQRRVVRKAFRKLAK 186

  Fly   285 KRVHGQKQTMTNDLVLVIMPDQLYRGTENTAKSKLYKLAENRVSKQRHRRRSRHEITKASVETFR 349
            .....|:|           |......|.::..|.....|..            ||  .||||...
Mouse   187 LNRRRQQQ-----------PSSPCSSTSSSTASSCSSSART------------HE--SASVERME 226

  Fly   350 TAIPSECNNNNYNVNNCIRRRKDKPLRNSVRYKLASLHADMNVRY-------------------- 394
            |.:.... :.::.:...::|.::.. |...||: |.:|.|...|:
Mouse   227 TLVHLVL-SQDHTIRQQVQRLRELD-REIDRYE-AKVHLDRMRRHGVNYVQDTYLVGAGIDLDGQ 288

  Fly   395 ------------------------EKEHALTRQLSEMC-RLYRLQNERYKGPEM----------E 424
                                    |.:.|...:|:..| .|.|||.||.:..|:          |
Mouse   289 TPEGEPEDATLEEKGTEPAAPLDSEAQAAALEELARRCDDLVRLQEERAQQEELLERLSAEIQEE 353

  Fly   425 LSVGQLQQNIEAYA--EDIIK----TEHELLELKNEIKHDI--SLINNLKRLT-LEESEAD 476
            |:...:|:..|..|  |:.::    .:.|||..:..::..:  ||...|:..| ||..:||
Mouse   354 LNQRWMQRRNEELAAREESLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLSTDLEAVKAD 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
meru	NP_001246779.1	None
Rassf10	NP_780488.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..81		5/29 (17%)
		UBQ	<88..132	CDD:294102	14/43 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..221		8/59 (14%)
		End3	<330..432	CDD:289527	23/85 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837019
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1574
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003658
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.830