DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment meru and Rassf8

DIOPT Version :9

Sequence 1:	NP_001246779.1	Gene:	meru / 39727	FlyBaseID:	FBgn0052150	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_082036.1	Gene:	Rassf8 / 71323	MGIID:	1918573	Length:	419	Species:	Mus musculus

Alignment Length:	403	Identity:	77/403 - (19%)
Similarity:	128/403 - (31%)	Gaps:	138/403 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 EIPIWMDDGEARYVSGVTNKTTCDDIIKALIDDELRNGNGFYCGNNPKDGGQRKTAAASRDYSDY 188
            |:.:|: ||..|.|.|||..|||.:::.||.....|.|.                         |
Mouse     2 ELKVWV-DGVQRIVCGVTEVTTCQEVVIALAQAIGRTGR-------------------------Y 40

  Fly   189 IITESWGGIERCYDGNMAILPVWRAWSRVHNELRISLKHRDSFRDPLAMQLVPHSQSATGFSMYK 253
            .:.|.|...||                                      .|.||.....  |:.|
Mouse    41 TLIEKWRDTER--------------------------------------HLAPHENPIV--SLNK 65

  Fly   254 W------LKKLLHLKKGKKTPPKPTKTPPKVPNKLKEKRVHGQKQTMTNDLVLVIMPDQLYRGTE 312
            |      ::.:|     ::|.|..::.|                   |:|.|..|....|||
Mouse    66 WGQYASDVQLIL-----RRTGPSLSERP-------------------TSDSVARIPERTLYR--- 103

  Fly   313 NTAKSKLYKLAENRVSKQRHRRRSRHEIT-------------KASVETFRTAIPSECNNNNYNVN 364
             .:...|.||........|.|...|..:|             |.....||..:.|.|
Mouse   104 -QSLPPLAKLRPQADKSIRRREPKRKSLTFTGGAKGLTDIFGKGKETEFRQKVLSNC-------- 159

  Fly   365 NCIRRRKDKPLRNSVRYKLASLHADMNVRYEKEHALTRQLSEMCRLYRLQNERYKGPEMELSVGQ 429
                |...:.|:..:|.:...|           .|:.:||.......|...::| ...:|..:.:
Mouse   160 ----RATAEELKRLIRLQTGKL-----------QAIEKQLESSEAEIRFWEQKY-SCSLEEEIVR 208

  Fly   430 LQQNIEAYAEDIIKTEHELLELKNEIKHDISLINNLKRLTLEESEADAACKKGAAKITHPLQENE 494
            |:|.|:....:|.:.|....||:.|.:::..|.:.|:.:..:.::.:...|...|:| |.::...
Mouse   209 LEQRIKRNDVEIEEEEFWENELQIEQENEKQLQDQLEEIRQKVTDCEGRLKDYLAQI-HTMESGL 272

  Fly   495 NTPQVAKNTQEMQ 507
            ...::.:..||.|
Mouse   273 QAEKLHREVQEAQ 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
meru	NP_001246779.1	None
Rassf8	NP_082036.1	RA_RASSF8	2..83	CDD:340551	29/151 (19%)
		Smc	109..>380	CDD:224117	39/202 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1574
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15286
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000