DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCP2 and DCP2

DIOPT Version :9

Sequence 1:	NP_001246776.1	Gene:	DCP2 / 39722	FlyBaseID:	FBgn0036534	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	NP_689837.2	Gene:	DCP2 / 167227	HGNCID:	24452	Length:	420	Species:	Homo sapiens

Alignment Length:	444	Identity:	164/444 - (36%)
Similarity:	224/444 - (50%)	Gaps:	82/444 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 EKSKIPSDILDDLASRFIINVPDMELNNLIRMCFQIELAHWFYLDFFCAPESGEDGETPKCVQRK 269
            ::.:||..:||||.||||:::|..|.:|.||:||||||||||||||:.....|
Human     4 KRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPG------------ 56

  Fly   270 LPSVGIKQFAMQLFQHIPFLNKHFGTVDQILDEWKNYKLSVPTYGAILVSEDHNHCLLVQSYFAR 334
            ||..||:.||..:|.|.|||......|:::|||||.||:.|||||||::.|...:.||||.|.|:
Human    57 LPQCGIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAK 121

  Fly   335 NSWGFPKGKINENEDPAHCATREVYEETGFDITDLIDANDYIEAFINYQYTRLYVVRNIPMDTQF 399
            :.|||||||:|:.|.|..||.|||:|||||||.|.|..:||||..||.|..|||::..||.||:|
Human   122 SGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKF 186

  Fly   400 APRTRNEIKCCDWFRIDALPVNKNDAISKAKLGKTSNSFFMIMPFVKRLKKWVNDRKAGIEPRRR 464
            .|:||.||:..:||.|:.||.::||...|:|||...|.|||.:||::.|:.|::.|.........
Human   187 NPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDN 251

  Fly   465 KFSGQQSPKAASPTNMNGNCKKDVTGVRNESQ--------------RQ--------RHKSMGDLD 507
            .||...| ..|.||..    |...|..|:..|              ||        .|..|.||
Human   252 GFSSTGS-TPAKPTVE----KLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKPYNNHSEMSDL- 310

  Fly   508 GVKLNNLNGKGTVGTGAGSAASASATAAINSMNICNSNGKRNKQNAAAGSNQATPTTIATPMTSN 572
                  |.||.                  .||   ..||::..|::   .||...|....|....
Human   311 ------LKGKN------------------QSM---RGNGRKQYQDS---PNQKKRTNGLQPAKQQ 345

  Fly   573 GAVVGGTVSSKRQLFHSQSQNDAQQSASNEKQIVSSFDLIRKEKQQQLKAAKAQ 626
            .::    :..:::|...:.|::.:..|        .:||....:.|.|:.|:.|
Human   346 NSL----MKCEKKLHPRKLQDNFETDA--------VYDLPSSSEDQLLEHAEGQ 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCP2	NP_001246776.1	DCP2	212..307	CDD:282833	45/94 (48%)
DCP2	NP_001246776.1	Dcp2p	310..459	CDD:239644	78/148 (53%)
DCP2	NP_689837.2	DCP2	12..93	CDD:309943	39/80 (49%)
		Dcp2p	97..246	CDD:239644	82/148 (55%)
		Nudix box	129..150		11/20 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..266		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..344		5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146958
Domainoid	1	1.000	133	1.000	Domainoid score	I5083
eggNOG	1	0.900	-	-		E1_COG0494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002974
OrthoInspector	1	1.000	-	-		oto90508
orthoMCL	1	0.900	-	-		OOG6_102623
Panther	1	1.100	-	-	LDO	PTHR23114
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R299
SonicParanoid	1	1.000	-	-		X2325
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.730