DRSC/TRiP Functional Genomics Resources

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Protein Alignment CkIIalpha-i1 and ZBTB16

DIOPT Version :10

Sequence 1:NP_524096.2 Gene:CkIIalpha-i1 / 39721 FlyBaseID:FBgn0015025 Length:410 Species:Drosophila melanogaster
Sequence 2:NP_005997.2 Gene:ZBTB16 / 7704 HGNCID:12930 Length:673 Species:Homo sapiens


Alignment Length:243 Identity:64/243 - (26%)
Similarity:95/243 - (39%) Gaps:48/243 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 CTCCG----HVLEILTHIRMHSCKPRPNPVYYCRDCGSEFHKLHELHEHMKTMKHNKTMCGAKDL 235
            |..||    ..|.:..|:..||...:   .:.|..||::|.|...|..|.:|  |..|     |:
Human   434 CELCGKRFLDSLRLRMHLLAHSAGAK---AFVCDQCGAQFSKEDALETHRQT--HTGT-----DM 488

  Fly   236 EFLCLRCNQIFPRYFDVIRHENSVHNVSDFICVECNMSFANQGSYRRHTRSHKVKFTQQRFYECP 300
            ...||.|.:.|.....:.:|......|..:||.|||.:|.:..:.:||.|||    |....|||.
Human   489 AVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSH----TGDHPYECE 549

  Fly   301 YKDCTSSYRVWARLMSHMSSH---------GLFSGFKSKVPSTQQERRLLEGKFMTLDPMKRVEP 356
            :  |.|.:|..:.|.||...|         |....|..| ...:...|:..|:          :|
Human   550 F--CGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLK-HQLETHYRVHTGE----------KP 601

  Fly   357 DRRKLPYRKKSFYA------KADFPESPTKCTNGGEFISLPKKISLQK 398
            ...||.:::...|:      :.....||.:||...|:  .|...|:||
Human   602 FECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEY--CPSLSSMQK 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CkIIalpha-i1NP_524096.2 C2H2 Zn finger 239..259 CDD:275368 5/19 (26%)
C2H2 Zn finger 267..287 CDD:275368 8/19 (42%)
C2H2 Zn finger 299..321 CDD:275368 7/21 (33%)
ZBTB16NP_005997.2 BTB_POZ_ZBTB16_PLZF 16..122 CDD:349514
PHA03307 177..>327 CDD:223039
Interaction with RUNX1T1. /evidence=ECO:0000269|PubMed:10688654 200..300
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 215..236
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 249..332
C2H2 Zn finger 406..426 CDD:275368
C2H2 Zn finger 434..454 CDD:275368 5/19 (26%)
COG5048 <448..622 CDD:227381 51/200 (26%)
C2H2 Zn finger 463..483 CDD:275368 8/21 (38%)
C2H2 Zn finger 492..512 CDD:275368 5/19 (26%)
C2H2 Zn finger 520..540 CDD:275368 8/19 (42%)
C2H2 Zn finger 548..568 CDD:275368 7/21 (33%)
C2H2 Zn finger 576..596 CDD:275368 4/20 (20%)
C2H2 Zn finger 604..624 CDD:275368 3/19 (16%)
C2H2 Zn finger 632..652 CDD:275368 7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

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