Protein Alignment CkIIalpha-i1 and ZNF66

DIOPT Version :10

• Sequence 1: NP_524096.2
• Gene: CkIIalpha-i1 / 39721
• FlyBaseID: FBgn0015025
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: XP_054185557.1
• Gene: ZNF66 / 7617
• HGNCID: 13135
• Length: 601
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 74/326 - (22%)
• Similarity: 116/326 - (35%)
• Gaps: 101/326 - (30%)

  Fly    21 EKP-KFKSANKLLQRLFDW-------YKIDAAILGENYCICEPCFGETLRISESLEKWGTAQDEF 77
            ||| |.:...|    .|:|       .:|..   ||....||.| |:..:.|.:|.|
Human   310 EKPYKCEECGK----AFNWSSHLTTHKRIHT---GEKPYKCEEC-GKGFKYSSTLTK-------- 358

  Fly    78 HR------RPIEIDD-STAFQIKLEVTSNKEEVETEKN----DEENSFDQHIAEPVKEDPLEKNE 131
            |:      :|.:.:: ..||:....:|::| .:.|.|.    :|.....:|      ..||.|::
Human   359 HKIIHTGEKPYKCEECGEAFKYSCSLTAHK-IIHTGKKPYKCEECGKVFKH------SSPLSKHK 416

  Fly   132 HMEIVVEESLKTASVDFFSVGLSRDGLAVTKFFKDKTQATRMLCTCCGHVLE----ILTHIRMHS 192
            .:.                        |..|.:|         |..||....    :.||..:|:
Human   417 RIH------------------------AGEKPYK---------CEECGKAFSRSSILTTHKIIHT 448

  Fly   193 C-KPRPNPVYYCRDCGSEFHKLHELHEHMKTMKHNKTMCGAKDLEFLCLRCNQIFPRYFDVIRHE 256
            . ||     |.|.|||..|::...|      .||.|...|.|  .:.|..|.:.| :...::...
Human   449 GEKP-----YECEDCGKAFNRSSNL------TKHKKIHTGEK--PYKCEECGKAF-KCSSILTTH 499

  Fly   257 NSVHNV-SDFICVECNMSFANQGSYRRHTRSHKVKFTQQRFYECPYKDCTSSYRVWARLMSHMSS 320
            ..:|.. ..:.|.||...|....:..||.|.|    |.::.|:|  ::|..::...|.|.||...
Human   500 KRIHTADKPYKCEECGKDFKYSSTLTRHKRIH----TGEKPYKC--EECGKAFNHPATLFSHKKI 558

  Fly   321 H 321
            |
Human   559 H 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CkIIalpha-i1	NP_524096.2	C2H2 Zn finger	239..259	CDD:275368	3/19 (16%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	299..321	CDD:275368	6/21 (29%)
ZNF66	XP_054185557.1	KRAB	4..64	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	176..195	CDD:275368
		COG5048	199..583	CDD:227381	74/326 (23%)
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368	3/23 (13%)
		C2H2 Zn finger	343..363	CDD:275368	8/28 (29%)
		C2H2 Zn finger	371..391	CDD:275368	4/20 (20%)
		C2H2 Zn finger	399..419	CDD:275368	5/25 (20%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		C2H2 Zn finger	455..475	CDD:275368	9/25 (36%)
		C2H2 Zn finger	483..503	CDD:275368	3/20 (15%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	6/21 (29%)
		C2H2 Zn finger	567..587	CDD:275368