DRSC/TRiP Functional Genomics Resources

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Protein Alignment CkIIalpha-i1 and ZNF253

DIOPT Version :10

Sequence 1:NP_524096.2 Gene:CkIIalpha-i1 / 39721 FlyBaseID:FBgn0015025 Length:410 Species:Drosophila melanogaster
Sequence 2:NP_066385.2 Gene:ZNF253 / 56242 HGNCID:13497 Length:499 Species:Homo sapiens


Alignment Length:527 Identity:109/527 - (20%)
Similarity:174/527 - (33%) Gaps:184/527 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 AIEIDLEKPKFKSANKLLQRLFDWYKIDAA-------ILGENY--------CICEPCFGETLRIS 64
            |||..||               :|:.:|.|       ::.|||        .:.:|.....|   
Human    10 AIEFSLE---------------EWHCLDTAQRNLYRDVMLENYRNLVFLGIVVSKPDLVTCL--- 56

  Fly    65 ESLEKWGTAQDEFHRRPIEIDDSTAFQIKLEVTSNKEEVETEKNDEENSFDQHIA---EPVKEDP 126
                       |..::|:.::..... .|..|.|:....:....:.:|||...:.   |..:.|.
Human    57 -----------EQGKKPLTMERHEMI-AKPPVMSSHFAQDLWPENIQNSFQIGMLRRYEECRHDN 109

  Fly   127 LEKNEHMEIVVE------------ESLKTASVDFFSVGLSRDGLAVTKFFKDKTQATR------M 173
            |:..:..:.|.|            :.|.|...:.|.  ..:.|....||....|..||      .
Human   110 LQLKKGCKSVGEHKVHKGGYNGLNQCLTTTQKEIFQ--CDKYGKVFHKFSNSNTYKTRHTGINLF 172

  Fly   174 LCTCCGHVLE----ILTHIRMHSC-KPRPNPVYYCRDCGSEFHKLHELHEHM------------- 220
            .|..||...:    :.||.::|:. ||     |.|.:||..|::...|..|.             
Human   173 KCIICGKAFKRSSTLTTHKKIHTGEKP-----YRCEECGKAFNQSANLTTHKRIHTGEKPYRCEE 232

  Fly   221 --KTMK-------HNKTMCGAKDLEFLCLRCNQIFPRYFDVIRHENSVHNVSDFICVECNMSFAN 276
              |..|       |.|...|.|  .:.|..|.:.|.|..|:..|:........:.|.||..:|  
Human   233 CGKAFKQSSNLTTHKKIHTGEK--PYKCEECGKAFNRSTDLTTHKIVHTGEKPYKCEECGKAF-- 293

  Fly   277 QGSYRRHTRSHKVKFTQQRFYEC------------------------PYK--DCTSSYRVWARLM 315
              .:..|..:||...|:.:.|.|                        |||  :|..::    .|.
Human   294 --KHPSHVTTHKKIHTRGKPYNCEECGKSFKHCSNLTIHKRIHTGEKPYKCEECGKAF----HLS 352

  Fly   316 SHMSSHG-LFSGFK--------------------SKVPSTQQERRLLE-GKFMT----LDPMKRV 354
            ||:::|. |.:|.|                    .|:.:.::..:..| ||..|    |...||.
Human   353 SHLTTHKILHTGEKPYRCRECGKAFNHSTTLFSHEKIHTGEKPYKCDECGKTFTWPSILSKHKRT 417

  Fly   355 EPDRRKLPYR----KKSFYAKADFP--------ESPTKCTNGGEF------ISLPKKISLQKGKY 401
            ....:  ||:    .|||.|.:...        |.|.||...|:.      ::..|||.:::..|
Human   418 HTGEK--PYKCEECGKSFTASSTLTTHKRIHTGEKPYKCEECGKAFNWSSDLNKHKKIHIERKPY 480

  Fly   402 I--NLSD 406
            |  |::|
Human   481 IVKNVTD 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CkIIalpha-i1NP_524096.2 C2H2 Zn finger 239..259 CDD:275368 6/19 (32%)
C2H2 Zn finger 267..287 CDD:275368 5/19 (26%)
C2H2 Zn finger 299..321 CDD:275368 8/47 (17%)
ZNF253NP_066385.2 KRAB 4..62 CDD:214630 14/80 (18%)
C2H2 Zn finger 146..166 CDD:275368 5/19 (26%)
COG5048 170..>497 CDD:227381 74/335 (22%)
C2H2 Zn finger 174..194 CDD:275368 5/19 (26%)
C2H2 Zn finger 202..222 CDD:275368 6/19 (32%)
C2H2 Zn finger 230..250 CDD:275368 4/19 (21%)
C2H2 Zn finger 258..278 CDD:275368 6/19 (32%)
C2H2 Zn finger 286..306 CDD:275368 7/23 (30%)
C2H2 Zn finger 314..334 CDD:275368 1/19 (5%)
C2H2 Zn finger 342..362 CDD:275368 5/23 (22%)
C2H2 Zn finger 370..390 CDD:275368 1/19 (5%)
C2H2 Zn finger 398..418 CDD:275368 7/19 (37%)
C2H2 Zn finger 426..446 CDD:275368 4/19 (21%)
C2H2 Zn finger 454..474 CDD:275368 4/19 (21%)

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