Protein Alignment CkIIalpha-i1 and ZNF506

DIOPT Version :10

• Sequence 1: NP_524096.2
• Gene: CkIIalpha-i1 / 39721
• FlyBaseID: FBgn0015025
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001092739.1
• Gene: ZNF506 / 440515
• HGNCID: 23780
• Length: 444
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 100/482 - (20%)
• Similarity: 160/482 - (33%)
• Gaps: 163/482 - (33%)

  Fly    15 AIEIDLEKPKFKSANKLLQRLFDWYKIDAA-------ILGENY--------CICEP----CFGE- 59
            |||..||               :|:.:|||       ::.|||        .:.:|    |..:
Human    10 AIEFSLE---------------EWHCLDAAQRNLYRDVMLENYRNLIFLGIVVSKPNLITCLEQG 59

  Fly    60 ----TLRISESLEKWGT-----AQDEFHRRPIEIDDSTAFQIKLEVTSNKEEVETEKNDEENSFD 115
                |::..|.:.|...     |||.:..:.|:  ||  ||   :|...:    .||...:|...
Human    60 KKPLTMKRHEMIAKPPVMYSHFAQDLWSEQSIK--DS--FQ---KVILRR----YEKCRHDNLQL 113

  Fly   116 QHIAEPVKEDPLEKNEHMEIVVEESLKTASVDFFSV-----------GLSRDGLAVT--KFFK-- 165
            :...|.|.|.|:.|..:..:  ::.|.|.....|..           ..::..:..|  |.||
Human   114 KKGCESVDECPVHKRGYNGL--KQCLATTQRKIFQCDEYVKFLHKFSNSNKHKIRDTGKKSFKCI 176

  Fly   166 --------DKTQAT---------RMLCTCCGHVLE----ILTHIRMH-----------------S 192
                    ..|:.|         |..|..||...:    :.||.::|                 |
Human   177 EYGKTFNQSSTRTTYKKIDAGEKRYKCEECGKAYKQSSHLTTHKKIHTGEKPYKCEECGKAYKQS 241

  Fly   193 CKPRPNPV-------YYCRDCGSEFHKLHELHEHMKTM-KHNKTMCGAKDLEFLCLRCNQIFPRY 249
            |....:.:       |.||:||..|:       |..|: .|.|...|.|  .:.|.:|.:.|...
Human   242 CNLTTHKIIHTGEKPYRCRECGKAFN-------HPATLFSHKKIHTGEK--PYKCDKCGKAFISS 297

  Fly   250 FDVIRHENSVHNVSDFICVECNMSFANQGSYRRHTRSHKVKFTQQRFYECPYK--DCTSSYRVWA 312
            ..:.:||........:.|.||..:|....:..:|.|.|.        .:.|||  :|..::..::
Human   298 STLTKHEIIHTGEKPYKCEECGKAFNRSSNLTKHKRIHT--------GDVPYKCDECGKTFTWYS 354

  Fly   313 RLMSHMSSHGLFSGFKSKVPSTQQERRLLEGKFMTLDPMKRVEPDRRKLPYRKKSFYAKADFPES 377
            .|..|..:|   :|.|   |...:|.......|.||...|.:...                  |.
Human   355 SLSKHKRAH---TGEK---PYKCEECGKAFTAFSTLTEHKIIHTG------------------EK 395

  Fly   378 PTKCTNGGEFISLPKKISLQKGKYINL 404
            |.||...|:..:...  :|.|.|.|::
Human   396 PYKCEECGKAFNWSS--ALNKHKKIHI 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CkIIalpha-i1	NP_524096.2	C2H2 Zn finger	239..259	CDD:275368	5/19 (26%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	299..321	CDD:275368	6/23 (26%)
ZNF506	NP_001092739.1	KRAB	4..62	CDD:214630	14/66 (21%)
		C2H2 Zn finger	147..167	CDD:275368	0/19 (0%)
		C2H2 Zn finger	175..195	CDD:275368	2/19 (11%)
		SFP1	<197..248	CDD:227516	9/50 (18%)
		C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	2/19 (11%)
		COG5048	<255..417	CDD:227381	46/204 (23%)
		C2H2 Zn finger	259..279	CDD:275368	9/26 (35%)
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		C2H2 Zn finger	343..363	CDD:275368	3/19 (16%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		C2H2 Zn finger	399..419	CDD:275368	5/21 (24%)