DRSC/TRiP Functional Genomics Resources

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Protein Alignment CkIIalpha-i1 and ZNF675

DIOPT Version :10

Sequence 1:NP_524096.2 Gene:CkIIalpha-i1 / 39721 FlyBaseID:FBgn0015025 Length:410 Species:Drosophila melanogaster
Sequence 2:NP_612203.2 Gene:ZNF675 / 171392 HGNCID:30768 Length:568 Species:Homo sapiens


Alignment Length:420 Identity:89/420 - (21%)
Similarity:148/420 - (35%) Gaps:123/420 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ISESLEKW---GTAQDEFHRRPI-EIDDSTAFQIKLEVTSNKEEVET--EKNDEENSFDQHIAEP 121
            |..|||:|   .|||...::..| |...:..|   |.:..:|:::.|  |:..|..:..:|  |.
Human    11 IEFSLEEWQCLDTAQRNLYKNVILENYRNLVF---LGIAVSKQDLITCLEQEKEPLTVKRH--EM 70

  Fly   122 VKEDPLEKNEH-MEIVVEESLKTASVDFFSVGLSRDGLAVTKFFKDK------------------ 167
            |.|.|:..:.. .|...|:::|.:   |..|.|.|........|:.|                  
Human    71 VNEPPVMCSHFAQEFWPEQNIKDS---FEKVTLRRYEKCGNDNFQLKGCKSVDECKLHKGGYNGL 132

  Fly   168 -----TQATRML-CTCCGHVLEILTHIRMHSCKPRPNPVYYCRDCGSEFHKLHELHEHMKTMKHN 226
                 |..::|. |.....|....:|...|..|...|..:.|::||..|..|..|..|    :.|
Human   133 NQCLPTMQSKMFQCDKYVKVFNKFSHSDRHKIKHMENKPFKCKECGRSFCMLSHLTRH----ERN 193

  Fly   227 KT---MCGAKDLE---------------------FLCLRCNQIFPRYFDVIRHENSVHNVSDFIC 267
            .|   .|..::.|                     :.|..|::.|.::.::..::........:.|
Human   194 YTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSNLTEYKKDYAREKPYKC 258

  Fly   268 VECNMSFANQGSYRRHTRSHKVKFTQQRFYECPYKDCTSSYRVWARLMSHMSSHGLFSGFKSKVP 332
            .||..:| ||.|   |..:||:..|.::.|:|  ::|..::..::.|.:|...|           
Human   259 EECGKAF-NQSS---HLTTHKIIHTGEKPYKC--EECGKAFNQFSNLTTHKKIH----------- 306

  Fly   333 STQQERRLLE--GKFM----TLDPMKRVEPDRRKLPYRKKSFYAKADFPESPTKCTNGGEFISLP 391
             |.::..:.|  ||..    ||...||:...                  |.|.||...|:..:..
Human   307 -TGEQPYICEECGKAFTQSSTLTTHKRIHTG------------------EKPYKCEECGKAFNRS 352

  Fly   392 KKISLQK--------------GKYINLSDN 407
            .|::..|              ||..|.|.|
Human   353 SKLTEHKNIHTGEQPYKCEECGKAFNRSSN 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CkIIalpha-i1NP_524096.2 C2H2 Zn finger 239..259 CDD:275368 3/19 (16%)
C2H2 Zn finger 267..287 CDD:275368 8/19 (42%)
C2H2 Zn finger 299..321 CDD:275368 4/21 (19%)
ZNF675NP_612203.2 KRAB 4..62 CDD:214630 15/53 (28%)
COG5048 169..556 CDD:227381 52/254 (20%)
C2H2 Zn finger 174..194 CDD:275370 7/23 (30%)
C2H2 Zn finger 202..222 CDD:275368 1/19 (5%)
C2H2 Zn finger 230..250 CDD:275368 3/19 (16%)
C2H2 Zn finger 258..278 CDD:275368 10/23 (43%)
C2H2 Zn finger 286..306 CDD:275368 4/21 (19%)
C2H2 Zn finger 314..334 CDD:275368 7/19 (37%)
C2H2 Zn finger 342..362 CDD:275368 4/19 (21%)
C2H2 Zn finger 370..390 CDD:275368 5/13 (38%)
C2H2 Zn finger 398..418 CDD:275368
C2H2 Zn finger 426..446 CDD:275368
C2H2 Zn finger 454..474 CDD:275368
C2H2 Zn finger 482..502 CDD:275368
C2H2 Zn finger 510..530 CDD:275368
C2H2 Zn finger 538..558 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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