DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant8 and GALNT12

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_078918.3	Gene:	GALNT12 / 79695	HGNCID:	19877	Length:	581	Species:	Homo sapiens

Alignment Length:	588	Identity:	185/588 - (31%)
Similarity:	277/588 - (47%)	Gaps:	94/588 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DIWRHKKKVLPLLLLMA---IGSIIYYLYTLKLEGERDESATSTTSRLERDIRD--LQAVFESEV 63
            ::.|.::.:|.||.|:|   :||:        |..:|...|.:......|..|.  .:.|.....
Human    13 ELRRGREALLVLLALLALAGLGSV--------LRAQRGAGAGAAEPGPPRTPRPGRREPVMPRPP 69

  Fly    64 IP--DLGALGRPARGNWTEEQLEAIAKSQRETGYNAWLSKRISPERSLYDMRHRSCKKLKYPMEK 126
            :|  .|||.|...|.....|:|....:|.|....|.:||.|||..|.|.:..:..||:.||..:.
Human    70 VPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKEKKYDYDN 134

  Fly   127 LPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEKLNDFIKIKFLNMVQH 191
            ||..||:|.::||..|.||||:.|:...:|..||.|||||||.|.:...|.....::..|..|:.
Human   135 LPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRL 199

  Fly   192 RRITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDTIDFDN 256
            .|...:.||:.||::||..|..|||.|||.|.|..:||||||:..|.|:......|:||.||::.
Human   200 IRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNT 264

  Fly   257 FAY--RRGKPSRGFFNWEFNYIQLPLLKEEAVAMPAP---HKNPIMNGGLFAIGREWFSELGGYD 316
            |.|  ..|:|..|.|:|...:....:.:.|.:.|.:|   .::|.|.|||||:.:::|..||.||
Human   265 FEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYD 329

  Fly   317 KGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKKLISRNYRRVA 381
            .|:::||.|..|.|.::|.|||.:...|||.|||:|..   |..|      |..|.:: |..|.|
Human   330 TGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPK---QAPY------SRNKALA-NSVRAA 384

  Fly   382 EIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLYPILDPAEYA 446
            |:|:||:|:..:...|...:.|.|::.|::.|:::|.||.|||||:       .:||.|...|..
Human   385 EVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLE-------TVYPELHVPEDR 442

  Fly   447 S---GVLQSISSPKLCLDRKDPSHGQPKLAPCSSDHVFPSPEQYWSLTNHRELRSGFYCLEVRNH 508
            .   |:||:......|.|...|...|                    :..|:
Human   443 PGFFGMLQNKGLTDYCFDYNPPDENQ--------------------IVGHQ-------------- 473

  Fly   509 GVNVHIYQCHGQSGNQFWSFDSK------THQVISGQQQNFRHCLEAQPELNAVTSSVCD---PK 564
               |.:|.|||...|||:.:.|:      |||.        ..|:..:..::.:...:|:   |:
Human   474 ---VILYLCHGMGQNQFFEYTSQKEIRYNTHQP--------EGCIAVEAGMDTLIMHLCEETAPE 527

  Fly   565 NHK 567
            |.|
Human   528 NQK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	118/303 (39%)
		pp-GalNAc-T	131..430	CDD:133004	118/303 (39%)
		Ricin_B_lectin	446..570	CDD:279046	25/134 (19%)
		RICIN	448..572	CDD:238092	25/129 (19%)
GALNT12	NP_078918.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..67		4/23 (17%)
		WcaA	134..429	CDD:223539	118/304 (39%)
		Catalytic subdomain A	135..244		49/108 (45%)
		pp-GalNAc-T	139..433	CDD:133004	118/310 (38%)
		Catalytic subdomain B	304..366		28/61 (46%)
		Ricin_B_lectin	445..574	CDD:279046	25/131 (19%)
		RICIN	447..576	CDD:238092	25/129 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810