Protein Alignment Pgant8 and Galnt1

DIOPT Version :10

• Sequence 1: NP_648800.1
• Gene: Pgant8 / 39715
• FlyBaseID: FBgn0036529
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_077349.1
• Gene: Galnt1 / 79214
• RGDID: 620358
• Length: 559
• Species: Rattus norvegicus
• Alignment Length: 528
• Identity: 183/528 - (34%)
• Similarity: 278/528 - (52%)
• Gaps: 63/528 - (11%)

  Fly    68 GALGRPARGNWTEEQLEAIAKSQRETGYNAWLSKRISPERSLYDMRHRSCKKLKYPMEKLPSVSV 132
            |.:|:|.  ...:|..|.:.:..:...:|...|:.|:..|||.|:|...||...|| :.||:.||
  Rat    59 GEMGKPV--VIPKEDQEKMKEMFKINQFNLMASEMIAFNRSLPDVRLEGCKTKVYP-DSLPTTSV 120

  Fly   133 VITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEKLNDFIK------IKFLNMVQH 191
            ||.:|||..|.||||:.|:.:|:|..::.|::||||.|.:      ||:|      :|.|.:..|
  Rat   121 VIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASER------DFLKRPLESYVKKLKVPVH 179

  Fly   192 -RRITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDTIDFD 255
             .|:..:.||:.||:.||.::...|:.|||:|.|.|.||||||:|.|..|.||...||||.|..|
  Rat   180 VIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCECTVGWLEPLLARIKHDRRTVVCPIIDVISDD 244

  Fly   256 NFAYRRGKP-SRGFFNWEFNYIQLPLLKEEAVAMPA----PHKNPIMNGGLFAIGREWFSELGGY 315
            .|.|..|.. :.|.|||:.|:...|:.:.|......    |.:.|.|.||||:|.|::|.|:|.|
  Rat   245 TFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTY 309

  Fly   316 DKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKKLISRNYRRV 380
            |.|:.|||.|..|:|.::|.|||.:..|.||.|||:||...   .||......:  :|::|.||:
  Rat   310 DAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKAT---PYTFPGGTGQ--IINKNNRRL 369

  Fly   381 AEIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLYPILD-PAE 444
            ||:|:||:|:..:...|.:|.:..|:::.:..|:::|.||||.|:|:       |:||... |..
  Rat   370 AEVWMDEFKNFFYIISPGVTKVDYGDISSRVGLRHKLQCKPFSWYLE-------NIYPDSQIPRH 427

  Fly   445 YAS-GVLQSISSPKLCLD---RKDPS-------HGQPKLAPCSSDHVFPSPEQYWSLTNHRELRS 498
            |.| |.::::.:.: |||   ||:..       ||.             ...|.:|.|.::|:|:
  Rat   428 YFSLGEIRNVETNQ-CLDNMARKENEKVGIFNCHGM-------------GGNQVFSYTANKEIRT 478

  Fly   499 GFYCLEVRNHGVNVHIYQCHGQSGNQFWSFDSKTHQVISGQQQNFRHCLEAQPELNAVTSSVCD- 562
            ...||:|......|.:.:||...|||.|.:|...   ::.|..|...||:...|.::...|:.|
  Rat   479 DDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVK---LTLQHVNSNQCLDKATEEDSQVPSIRDC 540

  Fly   563 PKNHKQQW 570
            ..:..|||
  Rat   541 TGSRSQQW 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	pp-GalNAc-T	131..430	CDD:133004	124/310 (40%)
		beta-trefoil_Ricin_Pgant8-like	445..573	CDD:467339	36/138 (26%)
Galnt1	NP_077349.1	Catalytic subdomain A	115..225		49/115 (43%)
		pp-GalNAc-T	119..419	CDD:133004	125/317 (39%)
		Catalytic subdomain B	285..347		31/61 (51%)
		beta-trefoil_Ricin_GALNT1	426..552	CDD:467344	36/140 (26%)