DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant8 and GALNT16

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001161840.1	Gene:	GALNT16 / 57452	HGNCID:	23233	Length:	558	Species:	Homo sapiens

Alignment Length:	601	Identity:	200/601 - (33%)
Similarity:	302/601 - (50%)	Gaps:	90/601 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KKKVLPLLLLMAIGSIIYYLYTLKLEGERDESATSTTSRLERDIRDLQAVFESEVIPDLGALGRP 73
            :...:.:|.:..|....|||:    :..|..:|:|.....:|..|..:.:.|...|| |...|.|
Human     5 RANAIAILTVAWILGTFYYLW----QDNRAHAASSGGRGAQRAGRRSEQLREDRTIP-LIVTGTP 64

  Fly    74 ARG-----NWTEEQLEAIAKSQRETGYNAWLSKRISPERSLYDMRHRSCKKLKYPMEKLPSVSVV 133
            ::|     ..:.:||:|.....|:..:|...|.::||:|.:.|.||.||..:.|..: ||:.||:
Human    65 SKGFDEKAYLSAKQLKAGEDPYRQHAFNQLESDKLSPDRPIRDTRHYSCPSVSYSSD-LPATSVI 128

  Fly   134 ITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADE--KLNDFIKIKFLNMVQHRRITT 196
            ||:|||..|.||||:.|:.:|||..|::|:|||||.|:..::  .|....|:|.|      |...
Human   129 ITFHNEARSTLLRTVKSVLNRTPANLIQEIILVDDFSSDPEDCLLLTRIPKVKCL------RNDR 187

  Fly   197 QVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDTIDFDNFAYRR 261
            :.||:.:||.||::|.|.||.|||||.||...||.|::..:.||:....:||||.|..|||||..
Human   188 REGLIRSRVRGADVAAATVLTFLDSHCEVNTEWLPPMLQRVKEDHTRVVSPIIDVISLDNFAYLA 252

  Fly   262 GKPS-RGFFNW--EFNYIQLPLLKEEAVAMPA-PHKNPIMNGGLFAIGREWFSELGGYDKGLKIW 322
            .... ||.|:|  .|.:.|:||.::.....|. |.:.|::.||:|.|.:.||:.||.||..:.||
Human   253 ASADLRGGFDWSLHFKWEQIPLEQKMTRTDPTRPIRTPVIAGGIFVIDKSWFNHLGKYDAQMDIW 317

  Fly   323 GAEQFELSLKLWLCGGQILEVPCSRVGHLFR--------DGNFQIRYTNKDKNSEKKLISRNYRR 379
            |.|.||||.::|:|||.:..||||||||:||        :|| .:.|.            ||.:|
Human   318 GGENFELSFRVWMCGGSLEIVPCSRVGHVFRKRHPYNFPEGN-ALTYI------------RNTKR 369

  Fly   380 VAEIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLYPILD-PA 443
            .||:|:||||...:...|.......|::|.:.:.:.:::||.|:|:|:       |:||.|. |.
Human   370 TAEVWMDEYKQYYYEARPSAIGKAFGSVATRIEQRKKMNCKSFRWYLE-------NVYPELTVPV 427

  Fly   444 EYA-SGVL-QSISSPKLCLDRKDPSHGQPK-------LAPCSSDHVFPSPEQYWSLTNHRELRSG 499
            :.| .|:: |.::    ||:    |.||..       :..|......|.|.|.|..::|...:.|
Human   428 KEALPGIIKQGVN----CLE----SQGQNTAGDFLLGMGICRGSAKNPQPAQAWLFSDHLIQQQG 484

  Fly   500 FYCLE-----VRNHGVNVHIYQCHGQSGNQFW----SFDSKTHQVISGQQQNFRHCLEAQPELNA 555
             .||.     :.:.|..|.:..|:.:.|.|.|    ||   ....:||.      |||.:|.  .
Human   485 -KCLAATSTLMSSPGSPVILQMCNPREGKQKWRRKGSF---IQHSVSGL------CLETKPA--Q 537

  Fly   556 VTSSVCDPKNHKQQWK 571
            :.:|.|......|||:
Human   538 LVTSKCQADAQAQQWQ 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	125/312 (40%)
		pp-GalNAc-T	131..430	CDD:133004	125/312 (40%)
		Ricin_B_lectin	446..570	CDD:279046	34/141 (24%)
		RICIN	448..572	CDD:238092	35/141 (25%)
GALNT16	NP_001161840.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..54		5/20 (25%)
		Catalytic subdomain A	122..227		51/110 (46%)
		pp-GalNAc-T	126..420	CDD:133004	126/319 (39%)
		Catalytic subdomain B	286..348		32/61 (52%)
		Ricin_B_lectin	441..543	CDD:395527	29/117 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152443
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740