Protein Alignment Pgant8 and GALNT9

DIOPT Version :10

• Sequence 1: NP_648800.1
• Gene: Pgant8 / 39715
• FlyBaseID: FBgn0036529
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_001116108.1
• Gene: GALNT9 / 50614
• HGNCID: 4131
• Length: 603
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 177/608 - (29%)
• Similarity: 285/608 - (46%)
• Gaps: 116/608 - (19%)

  Fly     7 RHKKKVLPLLLLMAIGSIIYYLYTLKLEGERDESATSTTSRLERDIR----------DLQAV--- 58
            |..:.:|.:.:|:.:|.:::.:| .:|:|...|.....:.  :|.:|          |.:|:
Human     5 RKIRTLLTVNILVFVGIVLFSVY-CRLQGRSQELVRIVSG--DRRVRSRHAKVGTLGDREAILQR 66

  Fly    59 ---FESEVIPDLGALGRP----------ARGNWT----EEQLEAIAKSQRETGYNAWLSKRISPE 106
               .|..|...|..|.:|          .:|...    ::..||..|.: |.||||.||.|||.:
Human    67 LDHLEEVVYNQLNGLAKPIGLVEGPGGLGQGGLAATLRDDGQEAEGKYE-EYGYNAQLSDRISLD 130

  Fly   107 RSLYDMRHRSCKKLKYPMEKLPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGST 171
            ||:.|.|.|.|:::.|..: ||.||||..:.||..||:||::.|:.:.||.|||:|||||||.|.
Human   131 RSIPDYRPRKCRQMSYAQD-LPQVSVVFIFVNEALSVILRSVHSVVNHTPSQLLKEVILVDDNSD 194

  Fly   172 QADEKLN--DFIKIKFLNMVQHRRITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLI 234
            ..:.|.|  .::..::..:|:..|.:.:.||:.||:.|.:.|.|.|:.|.|:|||...||.||.:
Human   195 NVELKFNLDQYVNKRYPGLVKIVRNSRREGLIRARLQGWKAATAPVVGFFDAHVEFNTGWAEPAL 259

  Fly   235 APILEDNRTCTTPIIDTIDFDNFAYRRGKPSRGFFNWEF--NYIQLPLLKEEAVAMPAPHKNPIM 297
            :.|.||.|....|.||.|.:..|..::...:...:||..  .||..|....:.....||.:.|.|
Human   260 SRIREDRRRIVLPAIDNIKYSTFEVQQYANAAHGYNWGLWCMYIIPPQDWLDRGDESAPIRTPAM 324

  Fly   298 NGGLFAIGREWFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYT 362
            .|..|.:.||:|.::|..|.|::::|.|..||.:::|.|||.:..:|||||.|:.|        |
Human   325 IGCSFVVDREYFGDIGLLDPGMEVYGGENVELGMRVWQCGGSMEVLPCSRVAHIER--------T 381

  Fly   363 NKDKNSE-KKLISRNYRRVAEIWLDEYKDKLFA--NMPHLTV-IPVGNLAEQRDLKNRLHCKPFK 423
            .|..|:: .....||..|.||:|:|::|..::.  |:|.... :..|:::|:..|:.||.|:.||
Human   382 RKPYNNDIDYYAKRNALRAAEVWMDDFKSHVYMAWNIPMSNPGVDFGDVSERLALRQRLKCRSFK 446

  Fly   424 WFLDNLATDFLNLYPIL----DPAEYASGVLQSISSPKLCLDR--KD-------PSHGQP----- 470
            |:|:       |:||.:    :...|  |.:::..:...|||:  :|       |.||..
Human   447 WYLE-------NVYPEMRVYNNTLTY--GEVRNSKASAYCLDQGAEDGDRAILYPCHGMSSQLVR 502

  Fly   471 -------KLAPCSSDHVFPS------------------------PEQYWSLTNHREL--RSGFYC 502
                   :|.|..|....|.                        .::.|..|....:  |:...|
Human   503 YSADGLLQLGPLGSTAFLPDSKCLVDDGTGRMPTLKKCEDVARPTQRLWDFTQSGPIVSRATGRC 567

  Fly   503 LEVR-----NHGVNVHIYQCHGQ 520
            |||.     |.|:.:.:.:|.||
Human   568 LEVEMSKDANFGLRLVVQRCSGQ 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	pp-GalNAc-T	131..430	CDD:133004	108/306 (35%)
		beta-trefoil_Ricin_Pgant8-like	445..573	CDD:467339	25/128 (20%)
GALNT9	NP_001116108.1	Catalytic subdomain A	150..261		47/110 (43%)
		pp-GalNAc-T	154..453	CDD:133004	109/313 (35%)
		Catalytic subdomain B	318..380		25/61 (41%)
		beta-trefoil_Ricin_GALNT9	456..600	CDD:467351	25/137 (18%)