DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant8 and GALNT8

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_059113.1	Gene:	GALNT8 / 26290	HGNCID:	4130	Length:	637	Species:	Homo sapiens

Alignment Length:	635	Identity:	194/635 - (30%)
Similarity:	303/635 - (47%)	Gaps:	103/635 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HKKKVLPLLLLMAIGSIIYYL-----------YTLKLEGERDESATSTTSRLERDIRDLQAVFES 61
            |::  |||.|....|::|..|           .::||...:.|:..||..|.:.::|.|....|:
Human    42 HRE--LPLHLNKRYGAVIKRLSHLEVELQDLKESMKLALRQQENVNSTLKRAKDEVRPLLKAMET 104

  Fly    62 EV------------IPDLGALGRPARGNWTEEQLEAIAKSQ----RETGYNAWLSKRISPERSLY 110
            :|            .|. ..|.|    .|.|:..||..|:.    |:.||||:||.::...|::.
Human   105 KVNETKKHKTQMKLFPH-SQLFR----QWGEDLSEAQQKAAQDLFRKFGYNAYLSNQLPLNRTIP 164

  Fly   111 DMRHRSCKKLKYPMEKLPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADE 175
            |.|...|.:..|| .:|||:||::.:.||..|::.|.::|:.:|||.:||:|:|||||.|:..:.
Human   165 DTRDYRCLRKTYP-SQLPSLSVILIFVNEALSIIQRAITSIINRTPSRLLKEIILVDDFSSNGEL 228

  Fly   176 KLNDFIKIKFLN--------MVQHRRITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEP 232
            |::...|||..|        :::|   ..:.||..||..|.|.|.|||:..||:|:||..||.||
Human   229 KVHLDEKIKLYNQKYPGLLKIIRH---PERKGLAQARNTGWEAATADVVAILDAHIEVNVGWAEP 290

  Fly   233 LIAPILEDNRTCTTPIIDTIDFDNFAYRRGKPSRGFFNWEF--NYIQLPLLKEEAVAMPAPHKNP 295
            ::|.|.||.....:|:.|.|.||.|...:.:.:...||||.  .|..||....:...:.||.|:|
Human   291 ILARIQEDRTVIVSPVFDNIRFDTFKLDKYELAVDGFNWELWCRYDALPQAWIDLHDVTAPVKSP 355

  Fly   296 -IMNGGLFAIGREWFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGN-FQ 358
             ||  |:.|..|.:..|:|..|.|:.|:|.|..||||::|.|||::..:||||:.||.|... :.
Human   356 SIM--GILAANRHFLGEIGSLDGGMLIYGGENVELSLRVWQCGGKVEILPCSRIAHLERHHKPYA 418

  Fly   359 IRYTNKDKNSEKKLISRNYRRVAEIWLDEYKDKLFA--NMP-HLTVIPVGNLAEQRDLKNRLHCK 420
            :..|        ..:.||..||||||:||:|..::.  |:| ..:.|..|:::.:..|:.:|.||
Human   419 LDLT--------AALKRNALRVAEIWMDEHKHMVYLAWNIPLQNSGIDFGDVSSRMALREKLKCK 475

  Fly   421 PFKWFLDNLATDFLNLYPILDPAE--YASGVLQSISSPKLCLDRKDPSHGQPKLAPCSSDHVFPS 483
            .|.|:|.       |:||:|.|..  ...|.::::....:|||:.......|.:..|   |.|.|
Human   476 TFDWYLK-------NVYPLLKPLHTIVGYGRMKNLLDENVCLDQGPVPGNTPIMYYC---HEFSS 530

  Fly   484 PEQYWSLTNH-------RELRSGFYCLEVRNHGVNVHIYQCHGQSGNQ---FWSFDSKTHQVISG 538
            ...|:.||..       .|..:...||..........:..|...:.|:   :|.| .....||:
Human   531 QNVYYHLTGELYVGQLIAEASASDRCLTDPGKAEKPTLEPCSKAAKNRLHIYWDF-KPGGAVIN- 593

  Fly   539 QQQNFRHCLEAQPEL---NAVTSSVCDPKNHKQQWK-------FGYLNSQ 578
              ::.:.|||.:.:|   :.:....|.    .|.|:       :|..|||
Human   594 --RDTKRCLEMKKDLLGSHVLVLQTCS----TQVWEIQHTVRDWGQTNSQ 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	116/313 (37%)
		pp-GalNAc-T	131..430	CDD:133004	115/313 (37%)
		Ricin_B_lectin	446..570	CDD:279046	27/136 (20%)
		RICIN	448..572	CDD:238092	28/143 (20%)
GALNT8	NP_059113.1	transmembrane domain	7..29
		stem region	30..148		27/112 (24%)
		SMC_N	<48..>161	CDD:330553	29/117 (25%)
		GT1 motif	182..298		47/118 (40%)
		pp-GalNAc-T	184..485	CDD:133004	116/320 (36%)
		Gal/GalNAc transferase motif	358..397		17/40 (43%)
		RICIN	498..624	CDD:238092	28/136 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810