Protein Alignment Pgant8 and GALNT3

DIOPT Version :10

• Sequence 1: NP_648800.1
• Gene: Pgant8 / 39715
• FlyBaseID: FBgn0036529
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_004473.2
• Gene: GALNT3 / 2591
• HGNCID: 4125
• Length: 633
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 197/654 - (30%)
• Similarity: 311/654 - (47%)
• Gaps: 158/654 - (24%)

  Fly     3 LDIWRHKKKVLPLLLLMAIGSIIYYLYTLKLEGERDESA--TSTTSRLERDIRD--------LQA 57
            |.|.||..|     ....:|::|::...:.:..:|:.|.  :...||:||::::        |:|
Human    10 LHIKRHYHK-----KFWKLGAVIFFFIIVLVLMQREVSVQYSKEESRMERNMKNKNKMLDLMLEA 69

  Fly    58 VFE-SEVIPDLGALGRPAR------------GNWTEEQLEAI----------------------- 86
            |.. .:.:|.: .:|.|.|            |.:|..:|:.:
Human    70 VNNIKDAMPKM-QIGAPVRQNIDAGERPCLQGYYTAAELKPVLDRPPQDSNAPGASGKAFKTTNL 133

  Fly    87 ---AKSQRETG-----YNAWLSKRISPERSL-YDMRHRSCKKLKYP-MEKLPSVSVVITYHNEEA 141
               .:.::|.|     :||:.|.|||..|.| .|.|...|.:.|:. ...||:.||:|.:|||..
Human   134 SVEEQKEKERGEAKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAW 198

  Fly   142 SVLLRTLSSLRSRTPIQLLREVILVDDGSTQ--ADEKLNDFIK-IKFLNMVQHRRITTQVGLMHA 203
            |.||||:.|:...:|..||:|:|||||.|..  ..:||::::| ...:.:|:.|.   :.||:.|
Human   199 STLLRTVHSVLYSSPAILLKEIILVDDASVDEYLHDKLDEYVKQFSIVKIVRQRE---RKGLITA 260

  Fly   204 RVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDTIDFDNFAYRRGKP---- 264
            |::||.:|.|:.|.|||:|.|...||||||:|.|.|:.....:|.|.:||.:.|.:.:..|
Human   261 RLLGATVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGSN 325

  Fly   265 -SRGFFNW--EFNYIQLP-----LLKEEAVAMPAPHKNPIMNGGLFAIGREWFSELGGYDKGLKI 321
             :||.|:|  .|.:..||     ..|:|..    |.|.|...||||:|.:|:|..:|.||:.::|
Human   326 HNRGNFDWSLSFGWESLPDHEKQRRKDETY----PIKTPTFAGGLFSISKEYFEYIGSYDEEMEI 386

  Fly   322 WGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKK---LISRNYRRVAEI 383
            ||.|..|:|.::|.||||:..:|||.|||:||         :|..:|..|   :|:||..|:||:
Human   387 WGGENIEMSFRVWQCGGQLEIMPCSVVGHVFR---------SKSPHSFPKGTQVIARNQVRLAEV 442

  Fly   384 WLDEYKDKLFANMPHLTVI----PVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLY-PILDPA 443
            |:||||:..:........|    ..|:|:::.::|:||.||.|.|:|:|:   :..:| |.|:|.
Human   443 WMDEYKEIFYRRNTDAAKIVKQKAFGDLSKRFEIKHRLQCKNFTWYLNNI---YPEVYVPDLNPV 504

  Fly   444 EYASGVLQSISSPKLCLDRKDPSHGQPKLAPCSSDHVFPSPEQYWSLTNHRELRSGFYCLEVRNH 508
              .||.::|:..| ||||..:.:.|
Human   505 --ISGYIKSVGQP-LCLDVGENNQG---------------------------------------- 526

  Fly   509 GVNVHIYQCHGQSGNQFWSFDSKTHQVISGQQQNFRHCLEAQPELNAVTSSVCDPKNHK------ 567
            |..:.:|.|||..|||::.: |..|::....|:..  ||.|...|  |....|..|.||
Human   527 GKPLIMYTCHGLGGNQYFEY-SAQHEIRHNIQKEL--CLHAAQGL--VQLKACTYKGHKTVVTGE 586

  Fly   568 QQWK 571
            |.|:
Human   587 QIWE 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	pp-GalNAc-T	131..430	CDD:133004	123/320 (38%)
		beta-trefoil_Ricin_Pgant8-like	445..573	CDD:467339	31/133 (23%)
GALNT3	NP_004473.2	Catalytic subdomain A	184..293		49/111 (44%)
		pp-GalNAc-T	188..493	CDD:133004	123/323 (38%)
		Catalytic subdomain B	356..418		30/61 (49%)
		beta-trefoil_Ricin_GALNT3	502..630	CDD:467346	32/137 (23%)