Protein Alignment Pgant8 and GALNT1

DIOPT Version :10

• Sequence 1: NP_648800.1
• Gene: Pgant8 / 39715
• FlyBaseID: FBgn0036529
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_065207.2
• Gene: GALNT1 / 2589
• HGNCID: 4123
• Length: 559
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 183/528 - (34%)
• Similarity: 278/528 - (52%)
• Gaps: 63/528 - (11%)

  Fly    68 GALGRPARGNWTEEQLEAIAKSQRETGYNAWLSKRISPERSLYDMRHRSCKKLKYPMEKLPSVSV 132
            |.:|:|.  ...:|..|.:.:..:...:|...|:.|:..|||.|:|...||...|| :.||:.||
Human    59 GEMGKPV--VIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYP-DNLPTTSV 120

  Fly   133 VITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEKLNDFIK------IKFLNMVQH 191
            ||.:|||..|.||||:.|:.:|:|..::.|::||||.|.:      ||:|      :|.|.:..|
Human   121 VIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASER------DFLKRPLESYVKKLKVPVH 179

  Fly   192 -RRITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDTIDFD 255
             .|:..:.||:.||:.||.::...|:.|||:|.|.|.||||||:|.|..|.||...||||.|..|
Human   180 VIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCECTVGWLEPLLARIKHDRRTVVCPIIDVISDD 244

  Fly   256 NFAYRRGKP-SRGFFNWEFNYIQLPLLKEEAVAMPA----PHKNPIMNGGLFAIGREWFSELGGY 315
            .|.|..|.. :.|.|||:.|:...|:.:.|......    |.:.|.|.||||:|.|::|.|:|.|
Human   245 TFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTY 309

  Fly   316 DKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKKLISRNYRRV 380
            |.|:.|||.|..|:|.::|.|||.:..|.||.|||:||...   .||......:  :|::|.||:
Human   310 DAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKAT---PYTFPGGTGQ--IINKNNRRL 369

  Fly   381 AEIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLYPILD-PAE 444
            ||:|:||:|:..:...|.:|.:..|:::.:..|:::|.||||.|:|:       |:||... |..
Human   370 AEVWMDEFKNFFYIISPGVTKVDYGDISSRVGLRHKLQCKPFSWYLE-------NIYPDSQIPRH 427

  Fly   445 YAS-GVLQSISSPKLCLD---RKDPS-------HGQPKLAPCSSDHVFPSPEQYWSLTNHRELRS 498
            |.| |.::::.:.: |||   ||:..       ||.             ...|.:|.|.::|:|:
Human   428 YFSLGEIRNVETNQ-CLDNMARKENEKVGIFNCHGM-------------GGNQVFSYTANKEIRT 478

  Fly   499 GFYCLEVRNHGVNVHIYQCHGQSGNQFWSFDSKTHQVISGQQQNFRHCLEAQPELNAVTSSVCDP 563
            ...||:|......|.:.:||...|||.|.:|...   ::.|..|...||:...|.::...|:.|.
Human   479 DDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVK---LTLQHVNSNQCLDKATEEDSQVPSIRDC 540

  Fly   564 K-NHKQQW 570
            . :..|||
Human   541 NGSRSQQW 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	pp-GalNAc-T	131..430	CDD:133004	124/310 (40%)
		beta-trefoil_Ricin_Pgant8-like	445..573	CDD:467339	36/138 (26%)
GALNT1	NP_065207.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..65		2/5 (40%)
		Catalytic subdomain A	115..225		49/115 (43%)
		pp-GalNAc-T	119..419	CDD:133004	125/317 (39%)
		Catalytic subdomain B	285..347		31/61 (51%)
		beta-trefoil_Ricin_GALNT1	426..552	CDD:467344	36/140 (26%)