DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant8 and Galnt18

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_776100.2	Gene:	Galnt18 / 233733	MGIID:	2446239	Length:	622	Species:	Mus musculus

Alignment Length:	621	Identity:	171/621 - (27%)
Similarity:	283/621 - (45%)	Gaps:	134/621 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLLMAIGSIIYYLYTLKLEGER-------DESATSTTSRLERDIRDLQAVF------------- 59
            ::.|:.:|.:..|:.::.:.|:.       :|....|...:|| :..|:.|.
Mouse    23 IICLLYVGWVTNYIASVYVRGQEPVPDKKLEEDKGDTLKIIER-LDHLENVIKQHIQEAPAKPEE 86

  Fly    60 -ESEVIPDLGALGRPARGNWTEE---QLEAIAKSQ-RETGYNAWLSKRISPERSLYDMRHRSCKK 119
             |:|...|....     .:|.:|   :...:|..| :..||||:||.|:..:|.|.|:|...|:.
Mouse    87 AEAEPFTDSSLF-----AHWGQELSPEGRRVALKQFQYYGYNAYLSDRLPLDRPLPDLRPSGCRN 146

  Fly   120 LKYPMEKLPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQAD--EKLNDFI- 181
            |.:| :.||.||:|..:.||..|||||::.|...|||..||:|:|||||.|:..:  |||.:::
Mouse   147 LSFP-DSLPEVSIVFIFVNEALSVLLRSIHSAMERTPSHLLKEIILVDDNSSNEELKEKLTEYVD 210

  Fly   182 -----KIKFLNMVQHRRITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDN 241
                 |..|:.:|:|.:   |.||:.:||.|...|.|.|:...|:|||...||.||::..|.|:.
Mouse   211 KVNGQKPGFIKVVRHSK---QEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENR 272

  Fly   242 RTCTTPIIDTIDFDNFAYRRGKPSRGFFNWEF--NYIQLPLLKEEAVAMPAPHKNPIMNGGLFAI 304
            :...:|..|.|.:|||.......:...|:||.  .|:..|....:.....||.::|.:. |.|.:
Mouse   273 KRIISPSFDNIKYDNFEIEEYPLAAQGFDWELWCRYLNPPKAWWKLENSTAPIRSPALI-GCFIV 336

  Fly   305 GREWFSELGGYDKGLKIWGAEQFELSLK---------------LWLCGGQILEVPCSRVGHLFRD 354
            .|::|.|:|..|:|::::|.|..||.::               :|.|||.:..:||||:.|:.|.
Mouse   337 DRQYFEEIGLLDEGMEVYGGENVELGIRVSEISHTGLSSAPMMVWQCGGSVEVLPCSRIAHIERA 401

  Fly   355 GNFQIRYTNKDKNSEKKLISRNYRRVAEIWLDEYKDKLFA--NMPHL-TVIPVGNLAEQRDLKNR 416
            ..   .|| :|..:.   :.||..||||:|:||:|..::.  |:|.. :.|.:|::..::.|:.:
Mouse   402 HK---PYT-EDLTAH---VRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQ 459

  Fly   417 LHCKPFKWFLDNLATDFLNLYPIL----DPAEYASGVLQSISSPKLCLDRKDPSHGQPKLAPCSS 477
            |.||.|:|:|       :::||.:    |...|  ||||:.....||||:...:...|
Mouse   460 LQCKTFRWYL-------VSVYPEMRMYSDIIAY--GVLQNSLKTDLCLDQGPDTENVP------- 508

  Fly   478 DHVFPSPEQYWSLTNHRELRSGFYCLEVRNHGVNVHIYQCHGQS-GNQFWSFDSKTHQVISGQ-- 539
                                               .:|.|||.: .|.:::...:.|..|...
Mouse   509 -----------------------------------IVYICHGMTPQNVYYTSSQQIHVGILSPTV 538

  Fly   540 QQNFRHCL---EAQPELNAVTSSVCDPKNHKQQWKF 572
            ..:...||   .::|.|  :..|....|..|..|:|
Mouse   539 DDDDNRCLVDVNSRPRL--IECSYAKAKRMKLHWQF 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	109/326 (33%)
		pp-GalNAc-T	131..430	CDD:133004	108/326 (33%)
		Ricin_B_lectin	446..570	CDD:279046	23/129 (18%)
		RICIN	448..572	CDD:238092	24/129 (19%)
Galnt18	NP_776100.2	Catalytic subdomain A	153..267		49/116 (42%)
		pp-GalNAc-T	157..473	CDD:133004	108/333 (32%)
		Catalytic subdomain B	324..400		23/76 (30%)
		Ricin_B_lectin	484..611	CDD:279046	26/135 (19%)
		RICIN	486..613	CDD:238092	25/131 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900