Protein Alignment Pgant8 and Galnt12

DIOPT Version :10

• Sequence 1: NP_648800.1
• Gene: Pgant8 / 39715
• FlyBaseID: FBgn0036529
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_766281.1
• Gene: Galnt12 / 230145
• MGIID: 2444664
• Length: 576
• Species: Mus musculus
• Alignment Length: 584
• Identity: 183/584 - (31%)
• Similarity: 274/584 - (46%)
• Gaps: 97/584 - (16%)

  Fly     7 RHKKKVLPLLLLMAIGSIIYYLYTLKLEGERDESATSTTS----RLERDIRDLQAVFESEVIP-- 65
            |.::.:|.||.|..:|:::           |..|.:.|..    |.....|. :.|.....:|
Mouse    16 RGREALLALLALAGLGALL-----------RARSRSGTVDPGPPRTPLPGRH-EPVLPRPPLPAD 68

  Fly    66 DLGALGRPARGNWTEEQLEAIAKSQRETGYNAWLSKRISPERSLYDMRHRSCKKLKYPMEKLPSV 130
            .|||.|...|.....|:|....:|.::...|.:||.|||..|.|.:..:..|:::||..:.||..
Mouse    69 ALGAHGEAVRLQLQGEELRLQEESVKQHQINIYLSDRISLHRRLPERWNPLCREVKYDYDNLPKT 133

  Fly   131 SVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEK------LNDFIKIKFLNMV 189
            ||||.::||..|.||||:.|:...:|..||.|||||||.|.:...|      |:...|::.:
Mouse   134 SVVIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSQLPKVRLI--- 195

  Fly   190 QHRRITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDTIDF 254
               |.:.:.||:.||::||..|..:||.|||.|.|..:||||||:..|.|.......|:||.||:
Mouse   196 ---RASRREGLVRARLLGASAARGEVLTFLDCHCECHEGWLEPLLQRIHEKESAVVCPVIDVIDW 257

  Fly   255 DNFAY--RRGKPSRGFFNWE--FNYIQLPLLKEEAVAMPAP-HKNPIMNGGLFAIGREWFSELGG 314
            :.|.|  ..|:|..|.|:|.  |.:..:|..:.:::..|.. .::|.|.|||||:.:.:|..||.
Mouse   258 NTFEYLGNSGEPQIGGFDWRLVFTWHVVPQRERQSMRSPIDVIRSPTMAGGLFAVSKRYFDYLGS 322

  Fly   315 YDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKKLISRNYRR 379
            ||.|:::||.|..|.|.::|.|||.:...|||.|||:|..   |..|      |..|.:: |..|
Mouse   323 YDTGMEVWGGENLEFSFRIWQCGGTLETHPCSHVGHVFPK---QAPY------SRSKALA-NSVR 377

  Fly   380 VAEIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLYPILDPAE 444
            .||:|:||:|:..:...|...:.|.|::.|::.|:.:|.||.||||||       .:||.|...|
Mouse   378 AAEVWMDEFKELYYHRNPQARLEPFGDVTERKKLRAKLQCKDFKWFLD-------TVYPELHVPE 435

  Fly   445 YAS---GVLQSISSPKLCLDRKDPSHGQPKLAPCSSDHVFPSPEQYWSLTNHRELRSGFYCLEVR 506
            ...   |:||:......|||...|:.                        ||.|
Mouse   436 DRPGFFGMLQNRGLRGYCLDYNPPNE------------------------NHVE----------- 465

  Fly   507 NHGVNVHIYQCHGQSGNQFWSFDSKTHQVISGQQQNFRHCLEAQPELNAVTSSVCD---PKNHK 567
              |..|.:|.|||...|||  |:..|.:.|....:....|:..:...:.:...:|.   |:|.:
Mouse   466 --GHQVLLYLCHGMGQNQF--FEYTTRKEIRYNTRQPEACITVEDGKDTLVMDLCRETVPENQE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	pp-GalNAc-T	131..430	CDD:133004	119/309 (39%)
		beta-trefoil_Ricin_Pgant8-like	445..573	CDD:467339	26/129 (20%)
Galnt12	NP_766281.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..58		4/20 (20%)
		Catalytic subdomain A	130..239		49/114 (43%)
		pp-GalNAc-T	134..428	CDD:133004	119/316 (38%)
		Catalytic subdomain B	299..361		28/61 (46%)
		beta-trefoil_Ricin-like	438..574	CDD:483949	26/127 (20%)