DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant8 and Galnt6

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001155239.1	Gene:	Galnt6 / 207839	MGIID:	1891640	Length:	622	Species:	Mus musculus

Alignment Length:	548	Identity:	184/548 - (33%)
Similarity:	284/548 - (51%)	Gaps:	83/548 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GALGRP-ARGNWTEEQLEAIAKSQRETGY-----NAWLSKRISPERSL-YDMRHRSCKKLKY-PM 124
            ||.|:. .:..||.     :...::|.||     ||:.|.|||.:||| .|.|...|...|: ..
Mouse   114 GADGKAFQKKEWTN-----LETKEKEEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRC 173

  Fly   125 EKLPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEKLNDFIKIKFLNMV 189
            ..||:.||:|.:|||..|.||||:.|:...:|..||:|:|||||.||  ||.|.:.:: :::..:
Mouse   174 PPLPTTSVIIVFHNEAWSTLLRTVYSVLHTSPAILLKEIILVDDAST--DEHLKERLE-QYVQQL 235

  Fly   190 QHRRITTQ---VGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDT 251
            |..|:..|   .||:.||::||.:|.|:||.|||:|.|...||||||:|.|.||.....:|.|.|
Mouse   236 QIVRVVRQRERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTAVVSPDIVT 300

  Fly   252 IDFDNFAY----RRGKP-SRGFFNWE--FNYIQLP-----LLKEEAVAMPAPHKNPIMNGGLFAI 304
            ||.:.|.:    :|||. |||.|:|.  |.:..||     ..|:|..    |.|:|...||||:|
Mouse   301 IDLNTFQFSRPVQRGKAHSRGNFDWSLTFGWEMLPEHEKQRRKDETY----PIKSPTFAGGLFSI 361

  Fly   305 GREWFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSE 369
            .:.:|..:|.||..::|||.|..|:|.::|.||||:..:|||.|||:||         .|..::.
Mouse   362 SKAYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFR---------TKSPHTF 417

  Fly   370 KK---LISRNYRRVAEIWLDEYKDKLF--ANMPHLTVIP---VGNLAEQRDLKNRLHCKPFKWFL 426
            .|   :|:||..|:||:|:|:|| |:|  .|:....::.   .|:::|:..|:.:|.|..|.|:|
Mouse   418 PKGTSVIARNQVRLAEVWMDDYK-KIFYRRNLQAAKMVQENNFGDISERLRLREQLRCHNFSWYL 481

  Fly   427 DNLATDFLNLYPILDPAEYASGVLQSISSPKLCLDRKDPSHGQPKLAPCSSDHVFPSPEQYWSLT 491
            .|:..:.  ..|.|:|..|  |.::::.:.: |||..:.:.|...|......::  ...||:..|
Mouse   482 HNVYPEM--FVPDLNPTFY--GAIKNLGTNQ-CLDVGENNRGGKPLIMYVCHNL--GGNQYFEYT 539

  Fly   492 NHRELRSGF---YCLEVRNHGVNVHIYQCHGQSG----NQFWSFDSKTHQVISGQQQNFRH---- 545
            :.|:||...   .||......:.:...|..|::.    ::.|...         |.|..|:
Mouse   540 SQRDLRHNIGKQLCLHASGSTLGLRSCQFVGKNSRVPKDEEWELT---------QDQLIRNSGSG 595

  Fly   546 -CLEAQPELNAVTSSVCDPKNHKQQWKF 572
             ||.:|.:..|:  :.|:|::..|.|.|
Mouse   596 TCLTSQDKKPAM--APCNPRDPYQLWLF 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	127/321 (40%)
		pp-GalNAc-T	131..430	CDD:133004	128/321 (40%)
		Ricin_B_lectin	446..570	CDD:279046	27/135 (20%)
		RICIN	448..572	CDD:238092	28/135 (21%)
Galnt6	NP_001155239.1	Catalytic subdomain A	176..285		52/111 (47%)
		pp-GalNAc-T	180..485	CDD:133004	128/321 (40%)
		Catalytic subdomain B	348..410		29/61 (48%)
		Ricin_B_lectin	497..619	CDD:366226	28/137 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842552
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740