DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant8 and gly-3

DIOPT Version :9

Sequence 1:	NP_648800.1	Gene:	Pgant8 / 39715	FlyBaseID:	FBgn0036529	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_498722.1	Gene:	gly-3 / 176112	WormBaseID:	WBGene00001628	Length:	612	Species:	Caenorhabditis elegans

Alignment Length:	633	Identity:	195/633 - (30%)
Similarity:	290/633 - (45%)	Gaps:	121/633 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLMAIGSIIYYLYTLKLEGERDESATSTTSRLERDIRDLQAVFESEVIP-----DLGALGRPARG 76
            ||:.:..:.|||          :.:||.......|.|.|......|.:|     |......|.:.
Worm    23 LLIDVVILFYYL----------DPSTSQQQPFPEDNRILNRARRIEPLPPAAQHDSDPDAHPIQP 77

  Fly    77 NWTEEQLEAIAK--------------------SQRETG-------------------YNAWLSKR 102
            ...|:|:..:.|                    .|..||                   :|...|:.
Worm    78 EKQEKQVYPVDKETANQLRKLMETQAFGPGYHGQGGTGVTVPEDKKTIKEKRFLENQFNVVASEM 142

  Fly   103 ISPERSLYDMRHRSCK----KLKYPMEKLPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREV 163
            ||..|:|.|.|..:|:    .||  ...:|..|::|.:|||..:.|||||.|:.:|:|..||.|:
Worm   143 ISVNRTLPDYRSDACRTSGNNLK--TAGMPKTSIIIVFHNEAWTTLLRTLHSVINRSPRHLLEEI 205

  Fly   164 ILVDDGSTQ--ADEKLNDFIKIKFLNMVQHRRITTQVGLMHARVVGAELALADVLVFLDSHVEVT 226
            |||||.|.:  ..:.|:.:||: |...:....:..:.||:.||:.|:|:|...:|:|||:|||||
Worm   206 ILVDDKSDRDYLVKPLDSYIKM-FPIPIHLVHLENRSGLIRARLTGSEMAKGKILLFLDAHVEVT 269

  Fly   227 KGWLEPLIAPILEDNRTCTTPIIDTIDFDNFAY-RRGKPSRGFFNWEFNYIQLPLLKEE----AV 286
            .||||||::.:.||.:....||||.|..|.|.| ...:.:.|.|||..|:....:.|.|    ..
Worm   270 DGWLEPLVSRVAEDRKRVVAPIIDVISDDTFEYVTASETTWGGFNWHLNFRWYAVPKRELNRRGS 334

  Fly   287 AMPAPHKNPIMNGGLFAIGREWFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHL 351
            ....|.:.|.:.||||||.:::|.::|.||:|:::||.|..|:|.::|:|||.:...|||||||:
Worm   335 DRSMPIQTPTIAGGLFAIDKQFFYDIGSYDEGMQVWGGENLEISFRVWMCGGSLEIHPCSRVGHV 399

  Fly   352 FRDGNFQIRYTNKDKNSEKKLISRNYRRVAEIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNR 416
            ||.   |..||  ......|:|..|..|.||:|:||||...:..:|....:..|:::|::.|:..
Worm   400 FRK---QTPYT--FPGGTAKVIHHNAARTAEVWMDEYKAFFYKMVPAARNVEAGDVSERKKLRET 459

  Fly   417 LHCKPFKWFLDNLATDFLNLYPILD-PAEYAS-GVLQSISSPKLCLDRKDPSHGQ-PKLAPCSSD 478
            |.||.|||:|:       |:||... ||::.| |.:.:..:.| |:|......|| |.:..|..
Worm   460 LQCKSFKWYLE-------NIYPEAPLPADFRSLGAIVNRFTEK-CVDTNGKKDGQAPGIQACHG- 515

  Fly   479 HVFPSPEQYWSLTNHRELRSGFYCL---EVRNHG------------VNV-HIYQCHGQSGNQFWS 527
               ....|.||||...|:||...||   .|...|            :|| |::....|:|.   .
Worm   516 ---AGGNQAWSLTGKGEIRSDDLCLSSGHVYQIGSELKLERCSVSKINVKHVFVFDDQAGT---L 574

  Fly   528 FDSKTHQVISGQQQNFRHCLEAQPELNAVTSSVCDPKNHKQQWKF-GY 574
            ...||.:.::|..|.             ||...|......|.|:. ||
Worm   575 LHKKTGKCVTGADQR-------------VTLDECGLGRKDQMWQLEGY 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant8	NP_648800.1	GT2	128..427	CDD:224137	121/305 (40%)
		pp-GalNAc-T	131..430	CDD:133004	121/305 (40%)
		Ricin_B_lectin	446..570	CDD:279046	34/141 (24%)
		RICIN	448..572	CDD:238092	34/140 (24%)
gly-3	NP_498722.1	pp-GalNAc-T	173..473	CDD:133004	122/312 (39%)
		Glyco_tranf_2_2	173..438	CDD:287123	110/270 (41%)
		Ricin_B_lectin	486..604	CDD:279046	33/138 (24%)
		RICIN	486..604	CDD:238092	33/138 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810